Prefrontal Cortical Deficits in Type 1 Diabetes Mellitus Brain Correlates of Comorbid Depression
DC Field | Value | Language |
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dc.contributor.author | Lyoo, In Kyoon | - |
dc.contributor.author | Yoon, Sujung | - |
dc.contributor.author | Jacobson, Alan M. | - |
dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Musen, Gail | - |
dc.contributor.author | Kim, Jieun E. | - |
dc.contributor.author | Simonson, Donald C. | - |
dc.contributor.author | Bae, Sujin | - |
dc.contributor.author | Bolo, Nicolas | - |
dc.contributor.author | Kim, Dajung J. | - |
dc.contributor.author | Weinger, Katie | - |
dc.contributor.author | Lee, Junghyun H. | - |
dc.contributor.author | Ryan, Christopher M. | - |
dc.contributor.author | Renshaw, Perry F. | - |
dc.date.accessioned | 2021-08-12T02:26:38Z | - |
dc.date.available | 2021-08-12T02:26:38Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0003-990X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14686 | - |
dc.description.abstract | Context: Neural substrates that may be responsible for the high prevalence of depression in type 1 diabetes mellitus (T1DM) have not yet been elucidated. Objective: To investigate neuroanatomic correlates of depression in T1DM. Design: Case-control study using high-resolution brain magnetic resonance images. Settings: Joslin Diabetes Center and McLean Hospital, Massachusetts, and Seoul National University Hospital, South Korea. Participants: A total of 125 patients with T1DM (44 subjects with >= 1 previous depressive episodes [T1DM-depression group] and 81 subjects who had never experienced depressive episodes [T1DM-only group]), 23 subjects without T1DM but with 1 or more previous depressive episodes (depression group), and 38 healthy subjects (control group). Main Outcome Measures: Spatial distributions of cortical thickness for each diagnostic group were compared with the control group using a surface-based approach. Among patients with T1DM, associations between metabolic control measures and cortical thickness deficits were examined. Results: Thickness reduction in the bilateral superior prefrontal cortical regions was observed in the T1DM-depression, T1DM-only, and depression groups relative to the control group at corrected P<.01. Conjunction analyses demonstrated that thickness reductions related to the influence of T1DM and those related to past depressive episode influence were observed primarily in the superior prefrontal cortical region. Long-term glycemic control levels were associated with superior prefrontal cortical deficits in patients with T1DM (beta=-0.19, P=.02). Conclusions: This study provides evidence that thickness reduction of prefrontal cortical regions in patients with T1DM, as modified by long-term glycemic control, could contribute to the increased risk for comorbid depression. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Medical Association | - |
dc.title | Prefrontal Cortical Deficits in Type 1 Diabetes Mellitus Brain Correlates of Comorbid Depression | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1001/archgenpsychiatry.2012.543 | - |
dc.identifier.scopusid | 2-s2.0-84870626646 | - |
dc.identifier.wosid | 000311804500009 | - |
dc.identifier.bibliographicCitation | Archives of General Psychiatry, v.69, no.12, pp 1267 - 1276 | - |
dc.citation.title | Archives of General Psychiatry | - |
dc.citation.volume | 69 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1267 | - |
dc.citation.endPage | 1276 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | HUMAN CEREBRAL-CORTEX | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE IMAGES | - |
dc.subject.keywordPlus | SURFACE-BASED ANALYSIS | - |
dc.subject.keywordPlus | POOR GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | COGNITIVE PERFORMANCE | - |
dc.subject.keywordPlus | MAJOR DEPRESSION | - |
dc.subject.keywordPlus | MOOD DISORDERS | - |
dc.subject.keywordPlus | BIDIRECTIONAL ASSOCIATION | - |
dc.subject.keywordPlus | STRUCTURAL ABNORMALITIES | - |
dc.subject.keywordPlus | COORDINATE SYSTEM | - |
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