Prefrontal Cortical Deficits in Type 1 Diabetes Mellitus Brain Correlates of Comorbid Depression
- Authors
- Lyoo, In Kyoon; Yoon, Sujung; Jacobson, Alan M.; Hwang, Jaeuk; Musen, Gail; Kim, Jieun E.; Simonson, Donald C.; Bae, Sujin; Bolo, Nicolas; Kim, Dajung J.; Weinger, Katie; Lee, Junghyun H.; Ryan, Christopher M.; Renshaw, Perry F.
- Issue Date
- Dec-2012
- Publisher
- American Medical Association
- Citation
- Archives of General Psychiatry, v.69, no.12, pp 1267 - 1276
- Pages
- 10
- Journal Title
- Archives of General Psychiatry
- Volume
- 69
- Number
- 12
- Start Page
- 1267
- End Page
- 1276
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14686
- DOI
- 10.1001/archgenpsychiatry.2012.543
- ISSN
- 0003-990X
- Abstract
- Context: Neural substrates that may be responsible for the high prevalence of depression in type 1 diabetes mellitus (T1DM) have not yet been elucidated. Objective: To investigate neuroanatomic correlates of depression in T1DM. Design: Case-control study using high-resolution brain magnetic resonance images. Settings: Joslin Diabetes Center and McLean Hospital, Massachusetts, and Seoul National University Hospital, South Korea. Participants: A total of 125 patients with T1DM (44 subjects with >= 1 previous depressive episodes [T1DM-depression group] and 81 subjects who had never experienced depressive episodes [T1DM-only group]), 23 subjects without T1DM but with 1 or more previous depressive episodes (depression group), and 38 healthy subjects (control group). Main Outcome Measures: Spatial distributions of cortical thickness for each diagnostic group were compared with the control group using a surface-based approach. Among patients with T1DM, associations between metabolic control measures and cortical thickness deficits were examined. Results: Thickness reduction in the bilateral superior prefrontal cortical regions was observed in the T1DM-depression, T1DM-only, and depression groups relative to the control group at corrected P<.01. Conjunction analyses demonstrated that thickness reductions related to the influence of T1DM and those related to past depressive episode influence were observed primarily in the superior prefrontal cortical region. Long-term glycemic control levels were associated with superior prefrontal cortical deficits in patients with T1DM (beta=-0.19, P=.02). Conclusions: This study provides evidence that thickness reduction of prefrontal cortical regions in patients with T1DM, as modified by long-term glycemic control, could contribute to the increased risk for comorbid depression.
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