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Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells
- Issue Date
- 28-Nov-2012
- Publisher
- Elsevier BV
- Keywords
- Paraptosis; Curcumin; Mitochondrial Ca2+; Proteasomal inhibition; Breast cancer
- Citation
- Cancer Letters, v.324, no.2, pp 197 - 209
- Pages
- 13
- Journal Title
- Cancer Letters
- Volume
- 324
- Number
- 2
- Start Page
- 197
- End Page
- 209
- ISSN
- 0304-3835
1872-7980
- Abstract
- In this study, we investigated the role of Ca2+ in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondria! Ca2+ overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na+/Ca2+ exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca2+ overload and effectively induce paraptosis in malignant breast cancer cells. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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Collections - College of Medicine > Department of Neurology > 1. Journal Articles
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