Bortezomib in combination with CHOP as first-line treatment for patients with stage III/IV peripheral T-cell lymphomas: A multicentre, single-arm, phase 2 trial
- Authors
- Kim, Seok Jin; Yoon, Dok Hyun; Kang, Hye Jin; Kim, Jin Seok; Park, Seong Kyu; Kim, Hyo Jung; Lee, Jeeyun; Ryoo, Baek-Yeol; Ko, Young Hyeh; Huh, Jooryung; Yang, Woo Ick; Kim, Hee Kyung; Min, Soo Kee; Lee, Seung-Sook; Do, In-Gu; Suh, Cheolwon; Kim, Won Seog
- Issue Date
- Nov-2012
- Publisher
- Pergamon Press Ltd.
- Keywords
- Bortezomib; CHOP; Peripheral T-cell lymphoma
- Citation
- European Journal of Cancer, v.48, no.17, pp 3223 - 3231
- Pages
- 9
- Journal Title
- European Journal of Cancer
- Volume
- 48
- Number
- 17
- Start Page
- 3223
- End Page
- 3231
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14734
- DOI
- 10.1016/j.ejca.2012.06.003
- ISSN
- 0959-8049
1879-0852
- Abstract
- Background: We performed a phase II study to evaluate the efficacy of bortezomib in combination with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) as first-line treatment for patients with stage III/IV peripheral T-cell lymphomas (PTCLs) based on our phase I study results. Methods: Patients received bortezomib on days 1 and 8 at a dose of 1.6 mg/m(2) in addition to CHOP every 3 weeks for a total of six cycles. Results: Forty-six patients were enrolled: PTCL, not otherwise specified (PTCL-NOS, n = 16), extranodal NK/T-cell lymphoma, nasal type (ENKTL, n = 10), angioimmunoblastic T-cell lymphoma (AITL, n = 8), ALK-negative anaplastic large-cell lymphoma (ALCL, n = 6), cutaneous T-cell lymphoma (CTCL, n = 5) and hepatosplenic T-cell lymphoma (n = 1). Thirty patients achieved complete response (CR, 65%) and the overall response rate was 76% (35/46). Although the CR rate of ENKTL was only 30% (3/10), three subtypes of PTCLs (PTCL-NOS, AITL and ALCL) showed 87% of overall response rate (ORR) (26/30) and 73% of CR rate (22/30). However, the 3-year overall survival and progression-free survival were 47% and 35%, respectively due to frequent relapse after remission. Grade 3/4 leucopenia was the most frequent toxicity whereas neurotoxicity was tolerable: grade 1 or 2 of peripheral neuropathy. Conclusions: The combined treatment of bortezomib and CHOP is an effective and feasible regimen for advanced-stage PTCLs other than ENKTL, with acceptable toxicity. However, future studies exploring new drug combinations are warranted to overcome relapse after remission. (C) 2012 Elsevier Ltd. All rights reserved.
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