CD55 polymorphisms and risk of aspirin-exacerbated respiratory disease
- Authors
- Lee, Jin Sol; Bae, Joon Seol; Kim, Jeong-Hyun; Kim, Jason Yongha; Park, Tae Joon; Pasaje, Charisse Flerida; Park, Byung-Lae; Cheong, Hyun Sub; Uh, Soo-Taek; Jang, An-Soo; Choi, Inseon S.; Park, Choon-Sik; Shin, Hyoung Doo
- Issue Date
- Nov-2012
- Publisher
- Spandidos Publications
- Keywords
- aspirin-exacerbated respiratory disease; aspirin-tolerant asthma; CD55; polymorphisms; haplotypes
- Citation
- Molecular Medicine Reports, v.6, no.5, pp 1087 - 1092
- Pages
- 6
- Journal Title
- Molecular Medicine Reports
- Volume
- 6
- Number
- 5
- Start Page
- 1087
- End Page
- 1092
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14741
- DOI
- 10.3892/mmr.2012.1064
- ISSN
- 1791-2997
1791-3004
- Abstract
- Aspirin-exacerbated respiratory disease (AERD) is a respiratory disease characterized by acute bronchial responses upon the administration of non-steroidal anti-inflammatory drugs (NSAIDs) and the immune response by mast cells is regarded as one of the noteworthy causes of AERD pathogenesis. The complement cascade is regarded as a key mechanism for clearing pathogens from the host. CD55 is one of the proteins involved in self-recognition, a central component of the complement system and autoimmunity. To investigate the associations between CD55 single nucleotide polymorphisms (SNPs) and the risk of AERD, we carried out logistic analyses with three genetic models and further regression analysis was performed with the fall rate of forced expiratory volume in 1 sec (FEV1) by aspirin provocation. However, our results demonstrate that no CD55 polymorphisms are associated with the risk of AERD and the fall rate of FEV1 (P>0.05). Therefore, our results suggest that CD55 polymorphisms are not genetic markers of aspirin-induced bronchospasm, including FEV1, in the population studied. Although the genetic role of CD55 has been found to be integral to human immunity, our results indicate that genetic variations of CD55 do not influence the risk of AERD and the fall rate of FEV1 in the population studied.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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