Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling
- Authors
- Son, Dong Ju; Kim, Soo Yeon; Han, Seong Su; Kim, Chan Woo; Kumar, Sandeep; Park, Byeoung Soo; Lee, Sung Eun; Yun, Yeo Pyo; Jo, Hanjoong; Park, Young Hyun
- Issue Date
- 19-Oct-2012
- Publisher
- Academic Press
- Keywords
- Piperlongumine; Atherosclerosis; Vascular smooth muscle cells; PDGF receptor; NF-kappa B
- Citation
- Biochemical and Biophysical Research Communications, v.427, no.2, pp 349 - 354
- Pages
- 6
- Journal Title
- Biochemical and Biophysical Research Communications
- Volume
- 427
- Number
- 2
- Start Page
- 349
- End Page
- 354
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14758
- DOI
- 10.1016/j.bbrc.2012.09.061
- ISSN
- 0006-291X
1090-2104
- Abstract
- Piperlongumine (piplartine, PL) is an alkaloid found in the long pepper (Piper longum L) and has well-documented anti-platelet aggregation, anti-inflammatory, and anti-cancer properties; however, the role of PL in prevention of atherosclerosis is unknown. We evaluated the anti-atherosclerotic potential of PL in an in vivo murine model of accelerated atherosclerosis and defined its mechanism of action in aortic vascular smooth muscle cells (VSMCs) in vitro. Local treatment with PL significantly reduced atherosclerotic plaque formation as well as proliferation and nuclear factor-kappa B (NF-kappa B) activation in an in vivo setting. PL treatment in VSMCs in vitro showed inhibition of migration and platelet-derived growth factor BB (PDGF-BB)-induced proliferation to the in vivo findings. We further identified that PL inhibited PDGF-BB-induced PDGF receptor beta activation and suppressed downstream signaling molecules such as phospholipase C gamma 1, extracellular signal-regulated kinases 1 and 2 and Akt. Lastly, PL significantly attenuated activation of NF-kappa B-a downstream transcriptional regulator in PDGF receptor signaling, in response to PDGF-BB stimulation. In conclusion, our findings demonstrate a novel, therapeutic mechanism by which PL suppresses atherosclerosis plaque formation in vivo. (C) 2012 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > Department of Food Science and Nutrition > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.