Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Ho Won | - |
dc.contributor.author | Kim, Eui Han | - |
dc.contributor.author | Oh, Mee-Hye | - |
dc.date.accessioned | 2021-08-12T02:44:33Z | - |
dc.date.available | 2021-08-12T02:44:33Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.issn | 2092-8920 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14785 | - |
dc.description.abstract | Background: Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor progression, metastatic dissemination, and adverse outcomes, in several cancer types. In this study, we explored the clinicopathological significance of ezrin expression in non-small cell lung carcinomas (NSCLCs). Methods: Immunohistochemical analysis of tissue microarray with 112 surgically resected NSCLC specimens, was performed to examine the ezrin expression. We also correlated ezrin expression with other clinicopathological features and prognosis. Results: The ezrin-positive group revealed significantly higher correlation with pleural invasion (p = 0.016) and pathologic stage (p = 0.050). Univariate survival analysis showed that ezrin-positive group had a significantly shorter cancer-specific survival than ezrin-negative group (p = 0.016). Meanwhile, female (p = 0.030), no pleural invasion (p = 0.023), no lymphatic invasion (p = 0.026), and early pathologic stage (p = 0.008) significantly correlated with longer survival. Multivariate survival analysis showed that variables such as ezrin positivity (p = 0.032), female (p = 0.035), and early pathologic stage (p = 0.001) were independent prognostic factors for NSCLC. Conclusions: Ezrin might be a molecular marker to predict poor prognosis of NSCLC. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Pathologists | - |
dc.title | Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2012.46.5.470 | - |
dc.identifier.scopusid | 2-s2.0-84873898835 | - |
dc.identifier.wosid | 000310715600009 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pathology, v.46, no.5, pp 470 - 477 | - |
dc.citation.title | Korean Journal of Pathology | - |
dc.citation.volume | 46 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 470 | - |
dc.citation.endPage | 477 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001707044 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | ERM PROTEINS | - |
dc.subject.keywordPlus | LINKER EZRIN | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | MERLIN | - |
dc.subject.keywordAuthor | Carcinoma, non-small cell lung | - |
dc.subject.keywordAuthor | Ezrin | - |
dc.subject.keywordAuthor | Prognosis | - |
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