Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
- Authors
- Lee, Ho Won; Kim, Eui Han; Oh, Mee-Hye
- Issue Date
- Oct-2012
- Publisher
- Korean Society of Pathologists
- Keywords
- Carcinoma, non-small cell lung; Ezrin; Prognosis
- Citation
- Korean Journal of Pathology, v.46, no.5, pp 470 - 477
- Pages
- 8
- Journal Title
- Korean Journal of Pathology
- Volume
- 46
- Number
- 5
- Start Page
- 470
- End Page
- 477
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14785
- DOI
- 10.4132/KoreanJPathol.2012.46.5.470
- ISSN
- 1738-1843
2092-8920
- Abstract
- Background: Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor progression, metastatic dissemination, and adverse outcomes, in several cancer types. In this study, we explored the clinicopathological significance of ezrin expression in non-small cell lung carcinomas (NSCLCs). Methods: Immunohistochemical analysis of tissue microarray with 112 surgically resected NSCLC specimens, was performed to examine the ezrin expression. We also correlated ezrin expression with other clinicopathological features and prognosis. Results: The ezrin-positive group revealed significantly higher correlation with pleural invasion (p = 0.016) and pathologic stage (p = 0.050). Univariate survival analysis showed that ezrin-positive group had a significantly shorter cancer-specific survival than ezrin-negative group (p = 0.016). Meanwhile, female (p = 0.030), no pleural invasion (p = 0.023), no lymphatic invasion (p = 0.026), and early pathologic stage (p = 0.008) significantly correlated with longer survival. Multivariate survival analysis showed that variables such as ezrin positivity (p = 0.032), female (p = 0.035), and early pathologic stage (p = 0.001) were independent prognostic factors for NSCLC. Conclusions: Ezrin might be a molecular marker to predict poor prognosis of NSCLC.
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