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Lipase inhibitory activity of ethyl acetate fraction from Ecklonia cava extracts
- Issue Date
- Aug-2012
- Publisher
- 한국생물공학회
- Keywords
- seaweed; Ecklonia cava; lipase inhibitory activity; dieckol; anti-obesity agent
- Citation
- Biotechnology and Bioprocess Engineering, v.17, no.4, pp 739 - 745
- Pages
- 7
- Journal Title
- Biotechnology and Bioprocess Engineering
- Volume
- 17
- Number
- 4
- Start Page
- 739
- End Page
- 745
- ISSN
- 1226-8372
1976-3816
- Abstract
- Obesity is a key contributing risk factor to cardiovascular disease, certain cancers, and diabetes. Much effort has being made to investigate potential inhibitors against lipase from natural products. The ethyl acetate (EA) extract of Ecklonia cava (EC) were tested for their ability to inhibit pancreatic lipase activity in vitro. The 22 sub-fractions from EA extract were separated using silica gel column chromatography. Among the sub-fractions, the EA6 sub-fraction exhibited the highest inhibitory activity. Dieckol compound was isolated from the EA6 sub-fraction, which inhibited the lipase activity in a concentrationdependent manner with IC50 value at 0.26 mg/mL. These results suggest that EC has potential as a natural antiobesity agent.
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