Wireless Fast-Scan Cyclic Voltammetry to Monitor Adenosine in Patients With Essential Tremor During Deep Brain Stimulation
- Authors
- Chang, Su-Youne; Kim, Inyong; Marsh, Michael P.; Jang, Dong Pyo; Hwang, Sun-Chul; Van Gompel, Jamie J.; Goerss, Stephan J.; Kimble, Christopher J.; Bennet, Kevin E.; Garris, Paul A.; Blaha, Charles D.; Lee, Kendall H.
- Issue Date
- Aug-2012
- Publisher
- Mayo Medical Ventures
- Citation
- Mayo Clinic Proceedings, v.87, no.8, pp 760 - 765
- Pages
- 6
- Journal Title
- Mayo Clinic Proceedings
- Volume
- 87
- Number
- 8
- Start Page
- 760
- End Page
- 765
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14968
- DOI
- 10.1016/j.mayocp.2012.05.006
- ISSN
- 0025-6196
1942-5546
- Abstract
- Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release. (C) 2012 Mayo Foundation for Medical Education and Research Mayo Clin Proc. 2012;87(8):760-765
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- Appears in
Collections - College of Medicine > Department of Neurosurgery > 1. Journal Articles
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