Evaluation of formation process of spherical porous biphasic calcium phosphate (BCP) granules by slurry dripping method

Abstract

In this study, we investigated the formation behavior of spherical porous biphasic calcium phosphate (BCP) granules, in which PCL was both the binder and fugitive pore former. The formation of porous granules was based on the immiscibility of PCL slurry containing BCP powder and distilled water. The porosity was controlled by controlling the volume fraction of PCL. In addition, the effect of the composition on the rheological properties and consequently the droplet formation mechanism was examined. After drying and sintering, the resulting BCP granules had a porous structure, which could promote stronger cell in-growth behavior. The method developed in this study can be utilized to successfully fabricate granules with controlled porosity and size.