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Suspected Anaphylactic Reaction Associated with Microemulsion Propofol during Anesthesia Induction

Authors
Lee, Se JinKim, Soon ImJung, Bo IlLee, Su MyungKim, Mun GyuPark, Sun YoungKim, Sang HoOk, Si Young
Issue Date
Jul-2012
Publisher
대한의학회
Keywords
Anaphylactic Reaction; Anesthetics; Aquafol; Complications; Microemulsion Propofol
Citation
Journal of Korean Medical Science, v.27, no.7, pp 827 - 829
Pages
3
Journal Title
Journal of Korean Medical Science
Volume
27
Number
7
Start Page
827
End Page
829
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15021
DOI
10.3346/jkms.2012.27.7.827
ISSN
1011-8934
1598-6357
Abstract
Although rare, intraoperative anaphylaxis can lead to significant morbidity and mortality. Aquafol (R) (Daewon Pharmaceutical Co. Ltd., Seoul, Korea), a microemulsion propofol, was developed to eliminate lipid solvent-related adverse events, and was used in clinical anesthesia since 2009 with little data about severe side effects such as anaphylaxis. A healthy 16-yr-old male patient who had past medical history with two previous operations of no complications developed cardiovascular shock with generalized erythema following administration of microemulsion propofol during anesthesia induction. Intravenous injection of epinephrine and steroid rescued him. He remained in a stable state without any problems postoperatively and was discharged. Clinicians should consider this rare but serious complication during induction of anesthesia with propofol.
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