Frequency of Bone Marrow Toxicity by Using Pattern of Azathioprine in Inflammatory Bowel Disease Patients
- Authors
- Hyun, Kyung Hee; Lee, Suck-Ho; Shin, Jae Min; Park, Dong Il; Lee, Chang Kyun; Shin, Jeong Eun; Eun, Chang Soo; Huh, Kyu Chan; Hwangbo, Young
- Issue Date
- Jul-2012
- Publisher
- 대한장연구학회
- Keywords
- Inflammatory Bowel Diseases; Azathioprine; Bone Marrow Toxicity
- Citation
- Intestinal research, v.10, no.3, pp 244 - 250
- Pages
- 7
- Journal Title
- Intestinal research
- Volume
- 10
- Number
- 3
- Start Page
- 244
- End Page
- 250
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15039
- DOI
- 10.5217/ir.2012.10.3.244
- ISSN
- 1598-9100
2288-1956
- Abstract
- Background/Aims: The most important adverse effect of azathioprine (AZA) is bone marrow toxicity (BMT). Many physicians have preferred a gradual dose increment (GDI) policy for the prevention of BMT. The aim of this study was to evaluate the efficacy of GDI for the prevention of AZA-induced BMT in inflammatory bowel disease (IBD) patients. Methods: The medical records of IBD patients who received AZA in 6 university hospitals were reviewed. The patients were divided into two groups: the GDI group (initial dose < 1.5 mg/kg, gradually increased to a therapeutic dose) and the non-GDI group (initial therapeutic dose >= 2 mg/kg). Results: A total of 308 patients were enrolled (male to female ratio, 1: 2.3; mean age, 34.91 +/- 14.19 years; ulcerative colitis, 43.5%; Crohn's disease, 55.2%; and intermediate colitis, 1.3%). The overall incidence of BMT was 16.2% (50/308). BMT developed most frequently between fourth to eighth week (26%, 13/50). The rate of BMT of the non-GDI group was significantly higher than that of the GDI group (27.5%, 11/40 vs. 14.6%, 39/268, P=0.038). A multivariate analysis showed that the only factor related to BMT was a non-GDI policy (P=0.036; odds ratio, 2.41; 95% confidence interval, 1.06-5.49). Conclusions: A GDI policy could be useful for reducing AZA-induced BMT in Korean IBD patients.
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Collections - College of Medicine > Department of Preventive Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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