The effect of cross-linking on the microstructure, mechanical properties and biocompatibility of electrospun polycaprolactone-gelatin/PLGA-gelatin/PLGA-chitosan hybrid composite
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thi-Hiep Nguyen | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-12T03:24:48Z | - |
dc.date.available | 2021-08-12T03:24:48Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 1468-6996 | - |
dc.identifier.issn | 1878-5514 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15115 | - |
dc.description.abstract | In this study, multilayered scaffolds composed of polycaprolactone (PCL)-gelatin/poly(lactic-co-glycolic acid) (PLGA)-gelatin/PLGA-chitosan artificial blood vessels were fabricated using a double-ejection electrospinning system. The mixed fibers from individual materials were observed by scanning electron microscopy. The effects of the cross-linking process on the microstructure, mechanical properties and biocompatibility of the fibers were examined. The tensile stress and liquid strength of the cross-linked artificial blood vessels were 2.3MPa and 340 mmHg, respectively, and were significantly higher than for the non-cross-linked vessel (2.0MPa and 120 mmHg). The biocompatibility of the cross-linked artificial blood vessel scaffold was examined using the MTT assay and by evaluating cell attachment and cell proliferation. The cross-linked PCL-gelatin/PLGA-gelatin/ PLGA-chitosan artificial blood vessel scaffold displayed excellent flexibility, was able to withstand high pressures and promoted cell growth; thus, this novel material holds great promise for eventual use in artificial blood vessels. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | National Institute for Materials Science and Elsevier BV Japan | - |
dc.title | The effect of cross-linking on the microstructure, mechanical properties and biocompatibility of electrospun polycaprolactone-gelatin/PLGA-gelatin/PLGA-chitosan hybrid composite | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1088/1468-6996/13/3/035002 | - |
dc.identifier.scopusid | 2-s2.0-84863825809 | - |
dc.identifier.wosid | 000306492500003 | - |
dc.identifier.bibliographicCitation | Science and Technology of Advanced Materials, v.13, no.3 | - |
dc.citation.title | Science and Technology of Advanced Materials | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BLOOD-VESSEL | - |
dc.subject.keywordPlus | VASCULAR PROSTHESIS | - |
dc.subject.keywordPlus | PLGA | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | ATTACHMENT | - |
dc.subject.keywordPlus | NANOFIBERS | - |
dc.subject.keywordAuthor | polycaprolactone | - |
dc.subject.keywordAuthor | gelatin | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | PLGA | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.