The effect of cross-linking on the microstructure, mechanical properties and biocompatibility of electrospun polycaprolactone-gelatin/PLGA-gelatin/PLGA-chitosan hybrid composite
- Authors
- Thi-Hiep Nguyen; Lee, Byong-Taek
- Issue Date
- Jun-2012
- Publisher
- National Institute for Materials Science and Elsevier BV Japan
- Keywords
- polycaprolactone; gelatin; chitosan; PLGA
- Citation
- Science and Technology of Advanced Materials, v.13, no.3
- Journal Title
- Science and Technology of Advanced Materials
- Volume
- 13
- Number
- 3
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15115
- DOI
- 10.1088/1468-6996/13/3/035002
- ISSN
- 1468-6996
1878-5514
- Abstract
- In this study, multilayered scaffolds composed of polycaprolactone (PCL)-gelatin/poly(lactic-co-glycolic acid) (PLGA)-gelatin/PLGA-chitosan artificial blood vessels were fabricated using a double-ejection electrospinning system. The mixed fibers from individual materials were observed by scanning electron microscopy. The effects of the cross-linking process on the microstructure, mechanical properties and biocompatibility of the fibers were examined. The tensile stress and liquid strength of the cross-linked artificial blood vessels were 2.3MPa and 340 mmHg, respectively, and were significantly higher than for the non-cross-linked vessel (2.0MPa and 120 mmHg). The biocompatibility of the cross-linked artificial blood vessel scaffold was examined using the MTT assay and by evaluating cell attachment and cell proliferation. The cross-linked PCL-gelatin/PLGA-gelatin/ PLGA-chitosan artificial blood vessel scaffold displayed excellent flexibility, was able to withstand high pressures and promoted cell growth; thus, this novel material holds great promise for eventual use in artificial blood vessels.
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Collections - College of Medicine > Department of Regenerative Medicine > 1. Journal Articles
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