Air trapping is a major determinant of persistent airway obstruction in asthmatics
- Authors
- Park, Sung-Woo; Park, Jai-Soung; Jeong, Sun Hye; Lee, Yun Nah; Hwangbo, Young; Park, Jong Sook; Lee, June Hyuk; Jang, An-Soo; Kim, Do-Jin; Uh, Soo Taek; Kim, Yong Hoon; Park, Choon-Sik
- Issue Date
- Jun-2012
- Publisher
- W. B. Saunders Co., Ltd.
- Keywords
- Asthma; Airway obstruction; Persistence; Air trapping; Lung CT; Inhaled corticosteroid
- Citation
- Respiratory Medicine, v.106, no.6, pp 786 - 793
- Pages
- 8
- Journal Title
- Respiratory Medicine
- Volume
- 106
- Number
- 6
- Start Page
- 786
- End Page
- 793
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15164
- DOI
- 10.1016/j.rmed.2012.02.012
- ISSN
- 0954-6111
1532-3064
- Abstract
- Chronic persistent airway obstruction has been observed in moderate-to-severe asthmatics despite treatment with inhaled corticosteroids. We investigated which airway changes were associated with this obstruction. High-resolution computed tomography (HRCT) was performed at study entry and reexamined at the time of follow-up when the FEV1 reached a maximally constant level after treatment for 1 year or more with inhaled corticosteroids. Bronchial wall area and air trapping extent were compared in the recovered group (n = 18) and the persistent airway obstruction group (n = 14). Bronchial wall area and air trapping of the initial HRCT were similar between the two groups. On follow-up HRCT, air trapping was markedly decreased in the recovered group compared with that on initial HRCT (P = 0.017), whereas bronchial wall area did not change. In the persistent-airway-obstruction group, these two parameters did not change during follow-up. When follow-up HRCT was compared, air trapping was significantly greater in the persistent-airway-obstruction group than in the recovered group (P = 0.003). Difference post-bronchodilator FEV1 value between at initial and 2nd HRCT exam was correlated with difference air trapping value between at initial and 2nd HRCT exam(%) on the follow-up HRCT (P = 0.017). The presence of persistent airflow obstruction were significantly associated with the air trapping % difference between initial and 2nd time (RR = 1.70, P = 0.018). Persistence of AT could be a main contributing factor to chronic persistent airflow obstruction in asthma. (C) 2012 Elsevier Ltd. All rights reserved.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Preventive Medicine > 1. Journal Articles
- College of Medicine > Department of Radiology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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