뇌졸중에서 우울증과 실행기능부전에 대한 고찰Depression and Executive Dysfunction in Stroke
- Other Titles
- Depression and Executive Dysfunction in Stroke
- Authors
- 나경세; 김신겸; 이소영; 정한용
- Issue Date
- 2012
- Publisher
- 대한생물정신의학회
- Keywords
- 뇌졸중; 우울증; 실행기능부전; 항우울제; Stroke; Depression; Executive dysfunction; Antidepressant
- Citation
- 생물정신의학, v.19, no.4, pp.179 - 786
- Journal Title
- 생물정신의학
- Volume
- 19
- Number
- 4
- Start Page
- 179
- End Page
- 786
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15579
- ISSN
- 1225-8709
- Abstract
- Depression and executive dysfunction are common neuropsychiatric sequelae of stroke. Patients with stroke are more predisposed to depression and executive dysfunction compared to patients with similar degree of physical disability. Both depression and executive dysfunction are also associated with poor prognosis such as high mortality and delayed recovery after stroke. Complex neurobiological and anatomical mechanisms are associated with the development of depression and executive dysfunction after stroke. Activation of pro-inflammatory cytokines is thought to be associated with onset of depression, whereas injuries in frontal-subcortical circuit are thought to be a link between depression and executive dysfunction. Early detection of depressive symptoms and both pharmacological and non-pharmacological treatment would be helpful. In this review paper, the authors investigated 1) biological and neuroanatomical substrate for poststroke depression and executive dysfunction, 2) the relationship and common etiopathology for poststroke depression and executive dysfunction, and 3) pharmacological and non-pharmacological treatment for poststroke depression. The contents of the paper are as follows : the prevalence, clinical manifestation, and biological etiology for poststroke depression, neuroanatomical abnormalities as a common etiological factor for depression and executive dysfunction, pharmacotherapy and non-pharmacological approach.
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