Parthenolide Inhibits Ovalbumin-Induced cyclooxygenase-2 and Inducible Nitric Oxide Synthase ExpressionParthenolide Inhibits Ovalbumin-Induced cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
- Other Titles
- Parthenolide Inhibits Ovalbumin-Induced cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
- Authors
- 윤형선
- Issue Date
- 2012
- Publisher
- 대한의생명과학회
- Keywords
- Cyclooxygenase-2; Egg allergy; NF-κB; Inducible nitric oxide synthase; Ovalbumin
- Citation
- 대한의생명과학회지, v.18, no.3, pp.319 - 323
- Journal Title
- 대한의생명과학회지
- Volume
- 18
- Number
- 3
- Start Page
- 319
- End Page
- 323
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15649
- Abstract
- In recent years, egg allergy has been raised as the most prevalent food hypersensitivity in the pediatric population.
One of the major egg allergens is ovalbumin (OVA) which is the major protein in egg white, comprising 54% of its total protein content. Parthenolide isolated from Tanacetum partheniumb has been used to treat many chronic diseases for many years. In the present report, we present biochemical evidence that parthenolide inhibits the nuclear factor-κB (NF-κB) activation induced by OVA. Parthenolide also inhibits OVA-induced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. These data suggest new approaches for the efficient alleviation of the allergic symptoms.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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