한국인에서 Neuregulin 3(NRG3) 유전자와 조현병의 연합 연구Association Analysis of Neuregulin 3 Gene with Schizophrenia in a Korean Population
- Other Titles
- Association Analysis of Neuregulin 3 Gene with Schizophrenia in a Korean Population
- Authors
- 신수진; 최종택; 김지원; 노양호; 박병래; 배준설; 신형두; 최인근; 한상우; 황재욱; 우성일
- Issue Date
- 2012
- Publisher
- 대한생물정신의학회
- Keywords
- NRG3; 조현병; 단염기 다형성; rs2295933; NRG3; Schizophrenia; Single nucleotide polymorphism; rs2295933
- Citation
- 생물정신의학, v.19, no.3, pp.128 - 133
- Journal Title
- 생물정신의학
- Volume
- 19
- Number
- 3
- Start Page
- 128
- End Page
- 133
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15659
- ISSN
- 1225-8709
- Abstract
- Objectives : Located on chromosome 10q22-q23, the human neuregulin 3 (NRG3) is suggested as a strong positional and functional candidate gene involved in the pathogenesis of schizophrenia. Several case-control studies examining the association between polymorphisms on NRG3 gene with schizophrenia and/or its traits (such as delusion) have been reported recently in cohorts of Han Chinese, Ashkenazi Jews, Australians, white Americans of Western European ancestry and Koreans. Thus, this study aimed to investigate the association of one SNP in exon 9 (rs2295933) of NRG3 gene with the risk of schizophrenia in a Korean population.
Methods : Using TaqMan assay, rs2295933 in the exon 9 of NRG3 was genotyped in 435 patients with schizophrenia as cases and 393 unrelated healthy individuals as controls. Differences in frequency distributions were analyzed using logistic regression models following various modes of genetic inheritance and controlling for age and sex as covariates.
Results : Subsequent analysis revealed that the frequency distribution of rs2295933 of NRG3 was not different between schizophrenia patients and healthy controls of Korean ethnicity.
Conclusions : This study does not support the role of NRG3 in schizophrenia in a Korean population.
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Collections - College of Medicine > Department of Psychiatry > 1. Journal Articles
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