흰쥐에서 염산-에탄올로 유발된 위염에 대한 HEAC 추출물과 그 주성분의 억제효과Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats
- Other Titles
- Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats
- Authors
- 최원식; 장도연; 이경락; 김승한
- Issue Date
- 2012
- Publisher
- 한국산학기술학회
- Keywords
- HEAC; Gastritis; Rat; Ethyl linoleate; 80% ethanol extract
- Citation
- 한국산학기술학회논문지, v.13, no.4, pp.1769 - 1776
- Journal Title
- 한국산학기술학회논문지
- Volume
- 13
- Number
- 4
- Start Page
- 1769
- End Page
- 1776
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15860
- DOI
- 10.5762/KAIS.2012.13.4.1769
- ISSN
- 1975-4701
- Abstract
- The purpose of this study is to evaluate the gastric mucosal damage effect by Hericium erinaceus cultibated with Artemisia capillaris (HEAC) with 0.15 M HCl in ethanol in rats. Among them, 80% ethanol extract showed potent inhibitory effect (67.7%) on gastritis. Using solvent fractionation, 80% ethanol extract of HEAC was separated into five fractions with n-hexane, methylene chloride, ethyl acetate, n-butanol and water. As a result, fractions obtained with methylene chloride exhibited strong inhibitory effects on gastritis. With this result, the methylene chloride extract was analyzed by GC/MS, HPLC, IR and NMR(1H, 13C) to identify primary active components and the main component in the extract was identified as ethyl linoleate. The effective does (ED50) values of 80% ethanol extract of HEAC and ethyl linoleate showed 22.6 and 6.4 mg/kg, respectively and these values were higher than those of stillen (44.2 mg/kg) and selbex (46.5 mg/kg). Therefore, the administration of 80% ethanol extract of HEAC and ethyl linoleate have a strong protective effect agasint the gastritis induced by HCl-ethanol and may be promising new drug for treating gastritis and gastric ulcer.
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Collections - College of Natural Sciences > Department of Life Science and Biotechnology > 1. Journal Articles
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