Effect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model
- Authors
- Kim, Dae Won; Hwang, Hyun Sook; Kim, Duk-Soo; Sheen, Seung Hoon; Heo, Dong Hwa; Hwang, Gyojun; Kang, Suk Hyung; Kweon, HaeYong; Jo, You-Young; Kang, Seok Woo; Lee, Kwang-Gill; Park, Kye Won; Han, Kyu Hyung; Park, Jinseu; Eum, Won Sik; Cho, Yong-Jun; Choi, Hyun Chul; Choi, Soo Young
- Issue Date
- 31-Dec-2011
- Publisher
- 생화학분자생물학회
- Keywords
- Inflammation; Protein therapy; Silk fibroin; Tat-superoxide dismutase; TPA
- Citation
- BMB Reports, v.44, no.12, pp 787 - 792
- Pages
- 6
- Journal Title
- BMB Reports
- Volume
- 44
- Number
- 12
- Start Page
- 787
- End Page
- 792
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15999
- DOI
- 10.5483/BMBRep.2011.44.12.787
- ISSN
- 1976-6696
1976-670X
- Abstract
- We investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative activity in a mouse model of inflammation. Inflammation was induced by topical treatment of mouse ears with 12-O-tetradecanoylphorbol-13-acetate (TPA). Histological, Western blot, and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or Tat-SOD alone could suppress elevated levels of cyclooxygenase-2, interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha induced by TPA. Moreover, silk fibroin peptide significantly enhanced the anti-inflammatory activity of Tat-SOD, although it had no influence on in vitro and in vivo transduction of Tat-SOD. Silk fibroin peptide exhibited anti-inflammatory activity in a mice model of inflammation. Therefore, silk fibroin peptide alone or in combination with Tat-SOD might be used as a therapeutic agent for various inflammatory diseases. [BMB reports 2011; 44(12): 787-792]
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Anatomy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15999)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.