Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | Choi, Ran | - |
dc.contributor.author | Kim, Bo Hwan | - |
dc.contributor.author | Naowaboot, Jarinyaporn | - |
dc.contributor.author | Lee, Mi Young | - |
dc.contributor.author | Hyun, Mi Ri | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Lee, Eun Soo | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Yang, Young Chul | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.date.accessioned | 2021-08-12T04:45:02Z | - |
dc.date.available | 2021-08-12T04:45:02Z | - |
dc.date.issued | 2011-12-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16001 | - |
dc.description.abstract | Diabetic nephropathy is the most serious complication in diabetes mellitus. It is known that oxidative stress and inflammation play a central role in the development of diabetic nephropathy. In this study, we investigated that ferulic acid (FA) known as anti-oxidative agent could effect on diabetic nephropathy by anti-oxidative and anti-inflammatory mechanism. We examined the effects of FA in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic control Long-Evans Tokushima Otsuka (LETO) rats. We treated FA to experimental rats from 26 to 45 weeks of age. We evaluated ACR, MDA and MCP-1 in 24 h urine and examined renal histopathology and morphologic change in extracted kidneys from rats. Also, we evaluated the ROS production and MCP-1 levels in cultured podocyte after FA treatment. In the FA-treated OLETF rats, blood glucose was significantly decreased and serum adiponectin levels were increased. Urinary ACR was significantly reduced in FA-treated OLETF rats compared with diabetic OLETF rats. In renal histopathology, FA-treated OLETF rats showed decreased glomerular basement membrane thickness, glomerular volume, and mesangial matrix expansion. FA treatment decreased oxidative stress markers and MCP-1 levels in 24 h urine of rats and supernatants of cultured podocyte. In conclusion, it was suggested that FA have protective and therapeutic effects on diabetic nephropathy by reducing oxidative stress and inflammation. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.3858/emm.2011.43.12.078 | - |
dc.identifier.scopusid | 2-s2.0-84855181872 | - |
dc.identifier.wosid | 000298576900004 | - |
dc.identifier.bibliographicCitation | Experimental & Molecular Medicine, v.43, no.12, pp 676 - 683 | - |
dc.citation.title | Experimental & Molecular Medicine | - |
dc.citation.volume | 43 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 676 | - |
dc.citation.endPage | 683 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001610260 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | VITAMIN-C | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | PODOCYTE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | diabetes mellitus | - |
dc.subject.keywordAuthor | experimental | - |
dc.subject.keywordAuthor | diabetic nephropathies | - |
dc.subject.keywordAuthor | ferulic acid | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | oxidative stress | - |
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