Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
- Authors
- Choi, Ran; Kim, Bo Hwan; Naowaboot, Jarinyaporn; Lee, Mi Young; Hyun, Mi Ri; Cho, Eun Ju; Lee, Eun Soo; Lee, Eun Young; Yang, Young Chul; Chung, Choon Hee
- Issue Date
- 31-Dec-2011
- Publisher
- 생화학분자생물학회
- Keywords
- diabetes mellitus; experimental; diabetic nephropathies; ferulic acid; inflammation; oxidative stress
- Citation
- Experimental & Molecular Medicine, v.43, no.12, pp 676 - 683
- Pages
- 8
- Journal Title
- Experimental & Molecular Medicine
- Volume
- 43
- Number
- 12
- Start Page
- 676
- End Page
- 683
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16001
- DOI
- 10.3858/emm.2011.43.12.078
- ISSN
- 1226-3613
2092-6413
- Abstract
- Diabetic nephropathy is the most serious complication in diabetes mellitus. It is known that oxidative stress and inflammation play a central role in the development of diabetic nephropathy. In this study, we investigated that ferulic acid (FA) known as anti-oxidative agent could effect on diabetic nephropathy by anti-oxidative and anti-inflammatory mechanism. We examined the effects of FA in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic control Long-Evans Tokushima Otsuka (LETO) rats. We treated FA to experimental rats from 26 to 45 weeks of age. We evaluated ACR, MDA and MCP-1 in 24 h urine and examined renal histopathology and morphologic change in extracted kidneys from rats. Also, we evaluated the ROS production and MCP-1 levels in cultured podocyte after FA treatment. In the FA-treated OLETF rats, blood glucose was significantly decreased and serum adiponectin levels were increased. Urinary ACR was significantly reduced in FA-treated OLETF rats compared with diabetic OLETF rats. In renal histopathology, FA-treated OLETF rats showed decreased glomerular basement membrane thickness, glomerular volume, and mesangial matrix expansion. FA treatment decreased oxidative stress markers and MCP-1 levels in 24 h urine of rats and supernatants of cultured podocyte. In conclusion, it was suggested that FA have protective and therapeutic effects on diabetic nephropathy by reducing oxidative stress and inflammation.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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