Clinical Outcome of Gastric Cancer Patients with Bone Marrow Metastases
- Authors
- Kwon, Ji Yeon; Yun, Jina; Kim, Han Jo; Kim, Kyoung-Ha; Kim, Se-Hyung; Lee, Sang-Cheol; Kim, Hyun Jung; Bae, Sang Byung; Kim, Chan Kyu; Lee, Nam Su; Lee, Kyu Taek; Park, Seong Kyu; Won, Jong-Ho; Hong, Dae Sik; Park, Hee Sook
- Issue Date
- Dec-2011
- Publisher
- 대한암학회
- Keywords
- Stomach neoplasms; Bone marrow; Neoplasm metastasis; Drug therapy
- Citation
- Cancer Research and Treatment, v.43, no.4, pp 244 - 249
- Pages
- 6
- Journal Title
- Cancer Research and Treatment
- Volume
- 43
- Number
- 4
- Start Page
- 244
- End Page
- 249
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16070
- DOI
- 10.4143/crt.2011.43.4.244
- ISSN
- 1598-2998
2005-9256
- Abstract
- Purpose The prognosis of gastric cancer patients with bone marrow metastases is extremely poor. The current study was conducted to evaluate the clinical outcomes of advanced gastric cancer patients with bone marrow metastases. Materials and Methods We retrospectively reviewed the medical records of 26 advanced gastric cancer patients with bone marrow metastases who were treated at Soonchunhyang University Hospital between September 1986 and February 2009. Results The median age was 46 years (range, 24 to 61 years). All patients had poorly differentiated adenocarcinoma, including 17 signet ring cell carcinomas. The majority of the patients had thrombocytopenia, anemia, and elevated lactate dehydrogenase levels. Sixteen patients (61.5%) received palliative chemotherapy (median, 4 cycles; range, 1 to 13 cycles). The median overall survival after detection of bone marrow metastases for the cohort of patients was 37 days (95% confidence interval, 12.5 to 61.5 days). The median overall survival after detection of bone marrow involvement was 11 days in the best supportive care group (range, 2 to 34 days) and 121 days (range, 3 to 383 days) in the palliative chemotherapy group (p<0.001). The causes of death were tumor progression (11 patients, 45%), brain hemorrhage (6 patients, 25%), infection (5 patients, 21%), and disseminated intravascular coagulation (1 patient, 4%). There were no chemotherapy-related deaths. Conclusion Palliative chemotherapy could be considered in advanced gastric cancer patients with bone marrow metastases as a treatment option.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16070)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.