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Proteomic Analysis of Hepatotoxicity Induced by Titanium Nanoparticles in Mouse Liver
- Authors
- Jeon, Yu-Mi; Park, Seul-Ki; Lee, Mi-Young
- Issue Date
- Dec-2011
- Publisher
- The Korean Society for Applied Biological Chemistry
- Keywords
- liver; mouse; proteomics; titanium nanoparticles; toxicity
- Citation
- Journal of the Korean Society for Applied Biological Chemistry, v.54, no.6, pp 852 - 859
- Pages
- 8
- Journal Title
- Journal of the Korean Society for Applied Biological Chemistry
- Volume
- 54
- Number
- 6
- Start Page
- 852
- End Page
- 859
- ISSN
- 1738-2203
- Abstract
- Differentially expressed proteins in mouse liver caused by toxicity of titanium nanoparticles (TiO2 NPs) were screened. More than 1,400 protein spots in mouse liver were detected by two-dimensional gel electrophoresis, and 15 proteins that showed greater than 2-fold expressional changes in response to TiO2 NPs were identified by liquid chromatography-tandem mass spectrometry. Of these, 12 proteins were down-regulated and 3 proteins were up-regulated upon treatment with TiO2 NPs. The 15 differentially expressed proteins could be used for detection of inflammation, apoptosis, and antioxidative reaction for treatment of acute hepatic damage by TiO2 NPs.
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Related Researcher
- Lee, Mi young
- College of Medical Sciences (Department of Medical Biotechnology)