Detailed Information

Cited 0 time in webofscience Cited 48 time in scopus
Metadata Downloads

Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes

Authors
Kim, Bo-YeonKim, Chul-HeeJung, Chan-HeeMok, Ji-OhSuh, Kyo-IlKang, Sung-Koo
Issue Date
Dec-2011
Publisher
Japan Endocrine Sociey/Nihon Naibunpi Gakkai
Keywords
Subclinical hypothyroidism; Type 2 diabetes mellitus; Microvascular complications; Diabetic retinopathy
Citation
Endocrine Journal, v.58, no.12, pp 1065 - 1070
Pages
6
Journal Title
Endocrine Journal
Volume
58
Number
12
Start Page
1065
End Page
1070
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16078
DOI
10.1507/endocrj.EJ11-0199
ISSN
0918-8959
1348-4540
Abstract
The association between subclinical hypothyroidism (SCH) and microvascular complications of type 2 diabetes is unclear. We examined whether SCH is associated with diabetic retinopathy or nephropathy in Korean patients with type 2 diabetes. Data from 489 patients who visited the diabetes clinic at a university hospital between 2001 and 2007 were analyzed retrospectively. Participants were evaluated for glycemic control, thyroid function, and diabetic retinopathy and nephropathy. Diabetic retinopathy was classified into five grades. Diabetic nephropathy was assessed by the presence of albuminuria. Patients in the SCH group had a higher proportion of women, older age, longer duration of diabetes, higher systolic and diastolic blood pressure, and higher insulin resistance index compared with the euthyroid group. No significant difference in family history of diabetes or body mass index was found between groups. The prevalence of severe diabetic retinopathy (severe nonproliferative diabetic retinopathy or proliferative diabetic retinopathy) was significantly higher in the SCH group than the euthyroid group (32.8% vs. 19.6%, P = 0.036), whereas no between-group difference was found in the prevalence of diabetic nephropathy. After adjustment for potential confounding factors (HbA1c, BMI, duration of diabetes, diabetic nephropathy, and hypertension) by multivariate logistic regression analysis, SCH remained significantly associated with severe diabetic retinopathy (odds ratio 2.086(95% CI, 1.010-4.307), P = 0.047). These results suggest that SCH was independently associated with severe diabetic retinopathy in patients with type 2 diabetes. Further prospective studies are required to confirm the association between SCH and diabetic retinopathy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Internal Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jung, Chan Hee photo

Jung, Chan Hee
College of Medicine (Department of Internal Medicine)
Read more

Altmetrics

Total Views & Downloads

BROWSE