Alterations in Serotonin Receptors and Transporter Immunoreactivities in the Hippocampus in the Rat Unilateral Hypoxic-induced Epilepsy Model
DC Field | Value | Language |
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dc.contributor.author | An, Sung-Jin | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.date.accessioned | 2021-08-12T04:46:47Z | - |
dc.date.available | 2021-08-12T04:46:47Z | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 0272-4340 | - |
dc.identifier.issn | 1573-6830 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16133 | - |
dc.description.abstract | Unilateral hypoxic-ischemia results in the frequent occurrence of interictal spikes, and occasionally sustained ictal discharges accompanied by a reduction in paired-pulse inhibition within the non-lesioned dentate gyrus. To elucidate the roles of serotonin (5-hydroxytryptamine [5-HT]) in an epileptogenic insult, we investigated the changes in 5-HT receptors and serotonin transporter (5-HTT) immunoreactivities within the lesioned and contralateral hippocampus following unilateral hypoxic-ischemia. During epileptogenic periods following hypoxic-ischemia, both 5-HT1A and 5HT(1B) receptor immunoreactivities were decreased within the lesioned and the non-lesioned hippocampus. However, 5-HTT immunoreactivity was transiently increased within the hippocampus bilaterally. These findings indicate that alteration of the 5-HT system results in a "diaschisis" pattern, and may contribute to neuronal death and the development of emotional disorders in epileptic patients accompanied by psychological stress. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | Alterations in Serotonin Receptors and Transporter Immunoreactivities in the Hippocampus in the Rat Unilateral Hypoxic-induced Epilepsy Model | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s10571-011-9726-x | - |
dc.identifier.scopusid | 2-s2.0-84860848274 | - |
dc.identifier.wosid | 000296090300013 | - |
dc.identifier.bibliographicCitation | Cellular and Molecular Neurobiology, v.31, no.8, pp 1245 - 1255 | - |
dc.citation.title | Cellular and Molecular Neurobiology | - |
dc.citation.volume | 31 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1245 | - |
dc.citation.endPage | 1255 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | 5-HT1A RECEPTOR | - |
dc.subject.keywordPlus | EXTRACELLULAR DOPAMINE | - |
dc.subject.keywordPlus | TRANSIENT ISCHEMIA | - |
dc.subject.keywordPlus | NEURONAL DAMAGE | - |
dc.subject.keywordPlus | NMDA RECEPTORS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | 5-HYDROXYTRYPTAMINE | - |
dc.subject.keywordAuthor | 5-HT1A receptor | - |
dc.subject.keywordAuthor | 5HT(1B) receptor | - |
dc.subject.keywordAuthor | 5-HTT | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Hypoxic-ischemia | - |
dc.subject.keywordAuthor | Epilepsy | - |
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