Alterations in Serotonin Receptors and Transporter Immunoreactivities in the Hippocampus in the Rat Unilateral Hypoxic-induced Epilepsy Model
- Authors
- An, Sung-Jin; Kim, Duk-Soo
- Issue Date
- Nov-2011
- Publisher
- Kluwer Academic/Plenum Publishers
- Keywords
- 5-HT1A receptor; 5HT(1B) receptor; 5-HTT; Hippocampus; Hypoxic-ischemia; Epilepsy
- Citation
- Cellular and Molecular Neurobiology, v.31, no.8, pp 1245 - 1255
- Pages
- 11
- Journal Title
- Cellular and Molecular Neurobiology
- Volume
- 31
- Number
- 8
- Start Page
- 1245
- End Page
- 1255
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16133
- DOI
- 10.1007/s10571-011-9726-x
- ISSN
- 0272-4340
1573-6830
- Abstract
- Unilateral hypoxic-ischemia results in the frequent occurrence of interictal spikes, and occasionally sustained ictal discharges accompanied by a reduction in paired-pulse inhibition within the non-lesioned dentate gyrus. To elucidate the roles of serotonin (5-hydroxytryptamine [5-HT]) in an epileptogenic insult, we investigated the changes in 5-HT receptors and serotonin transporter (5-HTT) immunoreactivities within the lesioned and contralateral hippocampus following unilateral hypoxic-ischemia. During epileptogenic periods following hypoxic-ischemia, both 5-HT1A and 5HT(1B) receptor immunoreactivities were decreased within the lesioned and the non-lesioned hippocampus. However, 5-HTT immunoreactivity was transiently increased within the hippocampus bilaterally. These findings indicate that alteration of the 5-HT system results in a "diaschisis" pattern, and may contribute to neuronal death and the development of emotional disorders in epileptic patients accompanied by psychological stress.
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