Altered PLC beta-1 expression in the gerbil hippocampal complex following spontaneous seizure
- Authors
- Lee, Saet-Byeol; Oh, Yun-Jung; Chung, Jae-Kwang; Jeong, Ji-Heon; Lee, Sang-Duk; Park, Dae-Kyoon; Park, Kyung-Ho; Ko, Jeong-Sik; Kim, Duk-Soo
- Issue Date
- 30-Sep-2011
- Publisher
- 생화학분자생물학회
- Keywords
- Epilepsy; Gerbil; Hippocampus; Immunohistochemistry; Phospholipase C (PLC)
- Citation
- BMB Reports, v.44, no.9, pp 566 - 571
- Pages
- 6
- Journal Title
- BMB Reports
- Volume
- 44
- Number
- 9
- Start Page
- 566
- End Page
- 571
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16205
- DOI
- 10.5483/BMBRep.2011.44.9.566
- ISSN
- 1976-6696
1976-670X
- Abstract
- Although the phospholipase C (PLC)beta-1 isoform is associated with spontaneous seizure and distinctively expressed in the telencephalon, the distribution of PLC beta-1 expression in the epileptic gerbil hippocampus remains controversial. Therefore, we determined whether PLC beta-1 is associated with spontaneous seizure in an animal model of genetic epilepsy. In the present study, PLC beta-1 immunoreactivity was down-regulated in seizure-sensitive (SS) gerbils more than in seizure-resistant (SR) gerbils. The expression of PLC beta-1 within calretinin (CR)positive neurons was rarely detected within the dentate hilar region of SS gerbils. PLC beta-1 immunoreactivity in the hippocampus was significantly elevated as compared to that in pre-seizure SS gerbil 3 h post-ictal. These findings suggest that alterations in PLC beta-1 immunoreactivity in the SS gerbil hippocampus may be closely related to the epileptic state of the gerbil brain and transiently elevated PLC beta-1 protein levels following seizure episodes. Such alterations may be compensatory responses in the SS gerbil hippocampus. [BMB reports 2011; 44(9) : 566-571]
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