Impact of IL2 and IL2RB Genetic Polymorphisms in Kidney Transplantation
- Authors
- Park, S. J.; Yoon, Y. C.; Kang, S. W.; Kim, T. H.; Kim, Y. W.; Joo, H.; Kim, H. J.; Jeong, K. H.; Lee, D. Y.; Lee, S. S.; Chung, J. H.; Kim, Y. H.
- Issue Date
- Jul-2011
- Publisher
- Appleton & Lange
- Citation
- Transplantation Proceedings, v.43, no.6, pp 2383 - 2387
- Pages
- 5
- Journal Title
- Transplantation Proceedings
- Volume
- 43
- Number
- 6
- Start Page
- 2383
- End Page
- 2387
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16360
- DOI
- 10.1016/j.transproceed.2011.06.014
- ISSN
- 0041-1345
1873-2623
- Abstract
- Patient genetic make-up may contribute to a higher risk for acute rejection episodes (AREs). Because interleukin-2 (IL2) and IL2 receptor beta (IL2RB) play key roles in immune modulation, we investigated the effect of single-nucleotide polymorphisms (SNPs) in the IL2 gene (rs2069762; T>G, promoter; and rs2069763; G>T, exon 1, Leu38Leu) and IL2RB gene (rs228942: C>A, exon 1, Asp391Glu; and rs228953: C>T, exon 8, Gly250Gly) on renal ARE risk in 61 ARE patients and 276 control renal allograft recipients in Korea. The genotype frequencies of the IL2 and IL2RB SNPs showed Hardy-Weinberg equilibrium in both ARE and control groups. No significant difference in the genotype frequencies of the 2 IL2 SNPs was detected between non-ARE and ARE subjects (P > .05). The occurrence of AREs was significantly associated with genetic variants of the IL2RB gene (rs228942: odds ratio [OR] 2.11, 95% confidence interval [CI] 1.19-3.74; P = .0096, dominant model; rs228953: OR 1.58, 95% CI 1.04-2.38; P = .029, codominant model). In the haplotype-based analysis, the AC haplotype of IL2RB (chi(2) = 4.738; P = .0295) showed associations with ARE. Our results demonstrate that genetic variants of IL2RB may be associated with the development of AREs and may help predict ARE risk in kidney transplantation patients.
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Collections - College of Medicine > Department of Clinical Pharmacology > 1. Journal Articles
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