Microstructural Alteration of the Anterior Cingulum is Associated With Apathy in Alzheimer Disease
- Authors
- Kim, Jee Wook; Lee, Dong Young; Choo, Il Han; Seo, Eun Hyun; Kim, Shin Gyeom; Park, Shin Young; Woo, Jong Inn
- Issue Date
- Jul-2011
- Publisher
- American Psychiatric Publishing, Inc.
- Keywords
- Alzheimer disease; anterior cingulum; apathy; diffusion tensor imaging; fractional anisotropy; gray matter density
- Citation
- American Journal of Geriatric Psychiatry, v.19, no.7, pp 644 - 653
- Pages
- 10
- Journal Title
- American Journal of Geriatric Psychiatry
- Volume
- 19
- Number
- 7
- Start Page
- 644
- End Page
- 653
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16385
- DOI
- 10.1097/JGP.0b013e31820dcc73
- ISSN
- 1064-7481
1545-7214
- Abstract
- Objectives: To identify regional alterations of white matter integrity associated with apathy in Alzheimer disease (AD). Design: Cross-sectional study. Setting: University Dementia Clinic. Participants: Fifty-one very mild or mild probable AD subjects. Intervention: Volumetric magnetic resonance imaging with diffusion tensor imaging. Measurements: Volume of interest analyses were performed to compare regional fractional anisotropy (FA) between apathy and apathy-free group, and to test linear relationship between regional FA and apathy severity. Apathy was assessed by the Neuropsychiatric Inventory. Results: Apathy group showed significantly lower FA values than apathy-free group in the left anterior cingulum (A-C), regardless of concomitant depression and psychotropic medications. Left A-C FA values also had significant linear relationship with apathy-composite scores as a measure of apathy severity, even after controlling gray matter density of the ipsilateral anterior cingulate cortex. Conclusions: Our findings support that communication failure between the anterior cingulate cortex and other brain structures via the A-C contributes to the development and aggravation of apathy in AD, additionally supporting the general notion of disconnection syndrome for clinical manifestation of AD. (Am J Geriatr Psychiatry 2011; 19:644-653)
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Psychiatry > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16385)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.