Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor
- Authors
- Kim, Chul Han; Lee, Jang Hyun; Won, Jong Ho; Cho, Moon Kyun
- Issue Date
- Jun-2011
- Publisher
- 대한의학회
- Keywords
- Mesenchymal Stem Cells; Wound Healing
- Citation
- Journal of Korean Medical Science, v.26, no.6, pp 726 - 733
- Pages
- 8
- Journal Title
- Journal of Korean Medical Science
- Volume
- 26
- Number
- 6
- Start Page
- 726
- End Page
- 733
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16505
- DOI
- 10.3346/jkms.2011.26.6.726
- ISSN
- 1011-8934
1598-6357
- Abstract
- We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of Sprague-Dawley rats. One site was covered with a 3D collagen gel containing 2 x 10(6) MSCs (MSCs+/3D collagen+). Another site was replaced with a 3D collagen gel without MSCs and the third site was left empty. The wound size was significantly reduced in the MSCs+/3D collagen+ sites. MSCs+/3D collagen+ sites exhibited the most neovascularization. FISH showed that Y-chromosome possessing cells were found within the dermis of MSCs+/3D collagen+ sites. Gelatin zymography revealed that the most intense expression of MMP-9 was detected early in the MSCs+/3D collagen+ sites. Our results indicate that MSCs upregulate the early expression of MMP-9 which induces the early mobilization of VEGF. Thus, MSCs appear to accelerate significantly wound healing via early activation of MMP-9 and VEGF.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Dermatology > 1. Journal Articles
- College of Medicine > Department of Plastic Surgery > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16505)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.