Preventive Strategies of Renal Insufficiency in Patients With Diabetes Undergoing Intervention or Arteriography (the PREVENT Trial)
- Authors
- Lee, Seung-Whan; Kim, Won-Jang; Kim, Young-Hak; Park, Seong-Wook; Park, Duk-Woo; Yun, Sung-Cheol; Lee, Jong-Young; Kang, Soo-Jin; Lee, Cheol Whan; Lee, Jae-Hwan; Choi, Si Wan; Seong, In-Whan; Suh, Jon; Cho, Yoon Haeng; Lee, Nae-Hee; Cheong, Sang-Sig; Yoo, Sang-Yong; Lee, Bong-Ki; Lee, Sang-Gon; Hyon, Min-Su; Shin, Won-Yong; Lee, Se-Whan; Jang, Jae-Sik; Park, Seung-Jung
- Issue Date
- 15-May-2011
- Publisher
- Excerpta Medica, Inc.
- Keywords
- Preventive Strategies of Renal Insufficiency
- Citation
- American Journal of Cardiology, v.107, no.10, pp 1447 - 1452
- Pages
- 6
- Journal Title
- American Journal of Cardiology
- Volume
- 107
- Number
- 10
- Start Page
- 1447
- End Page
- 1452
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16539
- DOI
- 10.1016/j.amjcard.2011.01.019
- ISSN
- 0002-9149
1879-1913
- Abstract
- Few studies have compared the ability of sodium bicarbonate plus N-acetylcysteine (NAC) and sodium chloride plus NAC to prevent contrast-induced nephropathy (CIN) in diabetic patients with impaired renal function undergoing coronary or endovascular angiography or intervention. Diabetic patients (n = 382) with renal disease (serum creatinine >= 1.1 mg/dl and estimated glomerular filtration rate <60 ml/min/1.73 m(2)) were randomly assigned to receive prophylactic sodium chloride (saline group, n = 189) or sodium bicarbonate (bicarbonate group, n = 193) before elective coronary or endovascular angiography or intervention. All patients received oral NAC 1,200 mg 2 times/day for 2 days. The primary end point was CIN, defined as an increase in serum creatinine >25% or an absolute increase in serum creatinine >= 0.5 mg/dl within 48 hours after contrast exposure. There were no significant between-group differences in baseline characteristics. The primary end point was met in 10 patients (5.3%) in the saline group and 17 (9.0%) in the bicarbonate group (p = 0.17), with 2 (1.1%) and 4 (2.1%), respectively, requiring hemodialysis (p = 0.69). Rates of death, myocardial infarction, and stroke did not differ significantly at 1 month and 6 months after contrast exposure. In conclusion, hydration with sodium bicarbonate is not superior to hydration with sodium chloride in preventing CIN in patients with diabetic nephropathy undergoing coronary or endovascular angiography or intervention. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;107:1447-1452)
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16539)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.