Fabrication and characterization of porous poly(lactic-co-glycolic acid) (PLGA) microspheres for use as a drug delivery system
- Authors
- Bao, Trinh-Quang; Hiep, Nguyen-Thi; Kim, Yang-Hee; Yang, Hun-Mo; Lee, Byong-Taek
- Issue Date
- Apr-2011
- Publisher
- Kluwer Academic Publishers
- Citation
- Journal of Materials Science, v.46, no.8, pp 2510 - 2517
- Pages
- 8
- Journal Title
- Journal of Materials Science
- Volume
- 46
- Number
- 8
- Start Page
- 2510
- End Page
- 2517
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16634
- DOI
- 10.1007/s10853-010-5101-4
- ISSN
- 0022-2461
1573-4803
- Abstract
- In this work, Simvastatin (SIM) loaded porous poly(lactic-co-glycolic acid) (PLGA) microspheres were fabricated using the W/O/W1/W2 double emulsion and solvent evaporation method. The optimal conditions for fabricating porous PLGA microspheres were determined to be 20% distilled water (v/v), 10% PLGA (m/v), and a 4:1 ratio of internal polyvinyl alcohol (PVA) to dichloromethane (DCM). The pores size distribution of porous PLGA microspheres was varied from 0.01 to 40 mu m, while their particle displayed a bimodal size distribution that had two diameter peaks at around 100 mu m and 500 mu m. The SIM encapsulation efficacy was found to be very high with a yield near 80% and the porous PLGA microspheres showed the excellent biocompatibility. In addition, the drug release profile was found to be significantly different from a temporal basis. Base on the combined results of this study, SIM loaded PLGA microspheres holds great promise for use in biomedical applications, especially in drug delivery system or tissue regeneration.
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- Appears in
Collections - College of Medicine > Department of Regenerative Medicine > 1. Journal Articles
- College of Medicine > Department of Physiology > 1. Journal Articles
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