A Polymorphism at-1607 2G in the Matrix Metalloproteinase-1 (MMP-1) Increased Risk of Sudden Deafness in Korean Population But Not at-519A/G in MMP-1
DC Field | Value | Language |
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dc.contributor.author | Nam, Sung-Il | - |
dc.contributor.author | Yu, Gyeong-Im | - |
dc.contributor.author | Kim, Hak-Jae | - |
dc.contributor.author | Park, Kyoung-Ok | - |
dc.contributor.author | Chung, Joo-Ho | - |
dc.contributor.author | Ha, Eunyoung | - |
dc.contributor.author | Shin, Dong-Hoon | - |
dc.date.accessioned | 2021-08-12T05:48:29Z | - |
dc.date.available | 2021-08-12T05:48:29Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0023-852X | - |
dc.identifier.issn | 1531-4995 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16817 | - |
dc.description.abstract | Objectives/Hypothesis: Matrix metalloproteinase-1 (MMP-1) is associated with a risk of inflammatory disease and cancer invasion. Two common etiologies for sudden deafness (SD) are circulatory disturbance and inflammation. The present study aimed to investigate whether MMP-1 polymorphisms are associated with SD. Study Design: Case-control study. Ninety-nine Korean SD patients and 530 normal patients (controls) were used in this study. Methods: Single nucleotide polymorphism (SNP) of MMP-1 (at -1607G/2G and -519A/G) was analyzed using the pyro-sequencing method. Results: At MMP-1 -1607G/2G, the distributions of 2G/2G, G/2G, and G/G genotypes in controls were 36.8%, 44.3%, and 18.9%, respectively, and in SD patients were 46.5%, 48.5%, and 5.1%, respectively. The 2G/2G genotype was found to increase the risk of SD compared with the G/G genotype (codominant model: P = .0029; recessive model: P = .0003). The 2G allele was found to increase the risk of SD compared with the G allele (P = .002). At MMP1 -519A/G, there was no statistically significant increase in the risk of SD. Among haplotypes of MMP-1 polymorphisms -1607G/2G and -519A/G, 2GA and GA were found to be associated with SD (P < .05). Conclusions: These results suggest that the 2G/2G genotype is associated with an increased risk of SD compared with the G/2G and G/G genotypes. Furthermore, the 2G allele may be a risk factor for SD. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | A Polymorphism at-1607 2G in the Matrix Metalloproteinase-1 (MMP-1) Increased Risk of Sudden Deafness in Korean Population But Not at-519A/G in MMP-1 | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/lary.21334 | - |
dc.identifier.scopusid | 2-s2.0-78651065963 | - |
dc.identifier.wosid | 000286400600029 | - |
dc.identifier.bibliographicCitation | Laryngoscope, v.121, no.1, pp 171 - 175 | - |
dc.citation.title | Laryngoscope | - |
dc.citation.volume | 121 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 175 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | SENSORINEURAL HEARING-LOSS | - |
dc.subject.keywordPlus | SINGLE NUCLEOTIDE POLYMORPHISM | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | Sudden deafness (SD) | - |
dc.subject.keywordAuthor | matrix metalloproteinase-1 (MMP-1) | - |
dc.subject.keywordAuthor | polymorphism | - |
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