A Polymorphism at-1607 2G in the Matrix Metalloproteinase-1 (MMP-1) Increased Risk of Sudden Deafness in Korean Population But Not at-519A/G in MMP-1
- Authors
- Nam, Sung-Il; Yu, Gyeong-Im; Kim, Hak-Jae; Park, Kyoung-Ok; Chung, Joo-Ho; Ha, Eunyoung; Shin, Dong-Hoon
- Issue Date
- Jan-2011
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- Sudden deafness (SD); matrix metalloproteinase-1 (MMP-1); polymorphism
- Citation
- Laryngoscope, v.121, no.1, pp 171 - 175
- Pages
- 5
- Journal Title
- Laryngoscope
- Volume
- 121
- Number
- 1
- Start Page
- 171
- End Page
- 175
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16817
- DOI
- 10.1002/lary.21334
- ISSN
- 0023-852X
1531-4995
- Abstract
- Objectives/Hypothesis: Matrix metalloproteinase-1 (MMP-1) is associated with a risk of inflammatory disease and cancer invasion. Two common etiologies for sudden deafness (SD) are circulatory disturbance and inflammation. The present study aimed to investigate whether MMP-1 polymorphisms are associated with SD. Study Design: Case-control study. Ninety-nine Korean SD patients and 530 normal patients (controls) were used in this study. Methods: Single nucleotide polymorphism (SNP) of MMP-1 (at -1607G/2G and -519A/G) was analyzed using the pyro-sequencing method. Results: At MMP-1 -1607G/2G, the distributions of 2G/2G, G/2G, and G/G genotypes in controls were 36.8%, 44.3%, and 18.9%, respectively, and in SD patients were 46.5%, 48.5%, and 5.1%, respectively. The 2G/2G genotype was found to increase the risk of SD compared with the G/G genotype (codominant model: P = .0029; recessive model: P = .0003). The 2G allele was found to increase the risk of SD compared with the G allele (P = .002). At MMP1 -519A/G, there was no statistically significant increase in the risk of SD. Among haplotypes of MMP-1 polymorphisms -1607G/2G and -519A/G, 2GA and GA were found to be associated with SD (P < .05). Conclusions: These results suggest that the 2G/2G genotype is associated with an increased risk of SD compared with the G/2G and G/G genotypes. Furthermore, the 2G allele may be a risk factor for SD.
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Collections - College of Medicine > Department of Clinical Pharmacology > 1. Journal Articles
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