Proteomic identification of the differentially expressed proteins in human lung epithelial cells by airborne particulate matter
DC Field | Value | Language |
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dc.contributor.author | Jeon, Yu Mi | - |
dc.contributor.author | Son, Bu Soon | - |
dc.contributor.author | Lee, Mi Young | - |
dc.date.accessioned | 2021-08-12T06:24:06Z | - |
dc.date.available | 2021-08-12T06:24:06Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0260-437X | - |
dc.identifier.issn | 1099-1263 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16827 | - |
dc.description.abstract | Exposure to airborne PM10, particulate matter with a median aerodynamic diameter of less than 10 mu m, is known to be associated with a number of adverse health effects. To gain a better understanding of the cytotoxic mechanism and to develop protein biomarker candidates for PM10-induced toxicity, proteomic analyses were performed in human lung epithelial cells. Two-dimensional gel electrophoresis (2-DE) was followed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) to analyze the proteins differentially expressed by exposure to PM10. Analysis of 2-DE gels revealed more than 1270 protein spots in the cells, of which 36 showed changes of more than 2-fold on exposure to PM10 (up-regulation, n = 6; down-regulation, n = 30). The glycolytic enzyme pyruvate kinase, which also plays a role in tumor metabolism, showed a marked increase in expression, whereas the cytoskeleton-related vinculin and anti-inflammatory annexin 1 showed marked decreases in expression. Copyright (C) 2010 John Wiley & Sons, Ltd. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Proteomic identification of the differentially expressed proteins in human lung epithelial cells by airborne particulate matter | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/jat.1566 | - |
dc.identifier.scopusid | 2-s2.0-78650502337 | - |
dc.identifier.wosid | 000286347000006 | - |
dc.identifier.bibliographicCitation | Journal of Applied Toxicology, v.31, no.1, pp 45 - 52 | - |
dc.citation.title | Journal of Applied Toxicology | - |
dc.citation.volume | 31 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 52 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | ANNEXIN-1 | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CLAUDIN-1 | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordAuthor | airborne particulate matter | - |
dc.subject.keywordAuthor | PM10 | - |
dc.subject.keywordAuthor | toxicity | - |
dc.subject.keywordAuthor | human lung epithelial cells | - |
dc.subject.keywordAuthor | proteomics | - |
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