The Effect of Metabolic Syndrome on Myocardial Contractile Reserve during Exercise in Non-Diabetic Hypertensive SubjectsThe Effect of Metabolic Syndrome on Myocardial Contractile Reserve during Exercise in Non-Diabetic Hypertensive Subjects
- Other Titles
- The Effect of Metabolic Syndrome on Myocardial Contractile Reserve during Exercise in Non-Diabetic Hypertensive Subjects
- Authors
- 하태훈; 서혜선; 추우진; 최재혁; 서존; 조윤행; 이내희
- Issue Date
- 2011
- Publisher
- Korean Society of Echocardiography
- Keywords
- Metabolic syndrome; Longitudinal contractile reserve; Hypertension.
- Citation
- Journal of Cardiovascular Imaging, v.19, no.4, pp 176 - 182
- Pages
- 7
- Journal Title
- Journal of Cardiovascular Imaging
- Volume
- 19
- Number
- 4
- Start Page
- 176
- End Page
- 182
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16980
- ISSN
- 2586-7210
2586-7296
- Abstract
- Background: Metabolic syndrome (MS) is associated with increased left ventricular (LV) mass and diastolic dysfunction. This study uses relatively load-independent Doppler tissue echocardiography to examine whether MS is associated with decreased longitudinal contractile reserve during dynamic exercise.
Methods: A total of 112 patients with relatively well-controlled, treated hypertension who complained of exertional dyspnea were enrolled (average age: 56.7 ± 10.5 years). Fifty-six were non-diabetic patients with MS (Group 1), and 56 were age-sex matched hypertensive patients without MS (Group 2). Exercise stress echo was performed using a symptom-limited, multistage,supine bicycle exercise test. Multiple Doppler parameters were obtained at baseline, at each stage of exercise, and during recovery.
Results: There was no significant difference between the two groups in terms of age, gender, and hemodynamic variables. E/E’, an index of LV filling pressure, was significantly higher in the MS group at rest and during exercise. The longitudinal contractile reserve, the change in S’ (longitudinal tissue velocity) from baseline to peak exercise, was significantly lower in the MS group (2.00 ± 1.65 vs. 2.90 ± 1.66, p = 0.015). Multiple regression analysis showed independent association of MS with longitudinal contractile reserve when controlled for confounding factors, such as LV mass index, gender, blood pressure, and age (β = -0.235, p = 0.035).
Conclusion: Longitudinal contractile reserve was reduced in MS patients compared to others, although both groups demonstrated similar longitudinal contractile function at rest. We present the first demonstration that metabolic syndrome is independently associated with LV systolic dysfunction during exercise in hypertensive patients.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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