Clinical features of acute viral hepatitis B in Korea: a multi-center studyClinical features of acute viral hepatitis B in Korea: a multi-center study
- Other Titles
- Clinical features of acute viral hepatitis B in Korea: a multi-center study
- Authors
- 최혜진; 고순영; 최원혁; 서연석; 김지훈; 변관수; 김영석; 김승업; 백순구; 정재연; 김태엽; 권오상; 김정한; 이창홍; 권소영
- Issue Date
- 2011
- Publisher
- 대한간학회
- Keywords
- Acute hepatitis B; Prevalence; Prognosis
- Citation
- Clinical and Molecular Hepatology, v.17, no.4, pp 307 - 312
- Pages
- 6
- Journal Title
- Clinical and Molecular Hepatology
- Volume
- 17
- Number
- 4
- Start Page
- 307
- End Page
- 312
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16989
- ISSN
- 2287-2728
2287-285X
- Abstract
- Background/Aims: The incidence of Hepatitis B has significantly declined since the introduction of an HBV vaccination program. The aim of this study was to investigate recent clinical features of acute viral hepatitis B (AVH-B) in Korea.
Methods: A total of 2241 patients with acute viral hepatitis were enrolled and their data were collected from nine medical-centers between January 2006 and December 2009. Results: One hundred nineteen (5.3%) of the 2241 were diagnosed as AVH-B. Among 78 patients with AVH-B whose data were analyzed, 50 were male, and the mean age was 38.6 years. In an initial test, mean AST, ALT and total-bilirubin levels were 1296.2 IU/L, 2109.6 IU/L and 9.3 mg/dl,respectively. Positivity frequencies for HBeAg and anti-HBe were 55.1% and 67.9%, respectively, and the mean HBV DNA level was 5.2 log10 copies/ml. The mean length of hospitalization was 11.6 days. During follow-up, AST, ALT and total bilirubin levels were normalized or near-normalized in all patients without serious complications. Sixty-three of 66 (95.4%)patients showed HBsAg loss and 37 (56.1%) patients showed HBsAg seroconversion. Only 3 patients (4.5%) showed persistent hepatitis B viremia. There was no case of death or liver transplantation. Nine patients (11.3%) had received anti-viral agents and their clinical outcomes were not significantly different from those of patients treated without antiviral agents. Conclusions: The prevalence of AVH-B among acute hepatitis patients is relatively low in Korea. AVH-B infection can be cured without complications in almost all patients, regardless of antiviral treatment.
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