하수오와 백하수오의 에탄올 추출물에 의한 B16/F10 Melanoma 세포주의 멜라닌 생성 억제효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서희 | - |
dc.contributor.author | 서근영 | - |
dc.contributor.author | 고수지 | - |
dc.contributor.author | 박영현 | - |
dc.date.accessioned | 2021-08-12T06:27:41Z | - |
dc.date.available | 2021-08-12T06:27:41Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1226-3311 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17115 | - |
dc.description.abstract | Anti-oxidative activity and tyrosinase inhibitory activity of various ethanol extracts of Polygoni multiflori radix (PMR) and Cynanchi wilfordii radix (CWR) were compared to identify an anti-oxidant and whitening agent source from nature. We conducted an investigation into the anti-oxidant activities of PMR and CWR ethanol extracts by measuring total polyphenol content, total flavonoid content, and ABTS radical capacity. The total polyphenol contents of PMR and CWR were 17.31±0.54 mg GA/eq g, and 2.75±0.22 mg GA/eq g, respectively. The total flavonoid contents of PMR and CWR were 6.38±0.39 mg naringine/eq g, and 1.34±0.09 mg naringine/eq g, respectively. The 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical decolorization of PMR and CWR were 96.89±0.21% at 1 mg/mL and 93.49±0.76% at 50 mg/mL. Melanoma cells were cultured with the PMR and CWR ethanol extracts for 48 hr, and total melanin content as a final product and the activity of tyrosinase, a key enzyme, in melanogenesis, were estimated. The PMR and CWR ethanol extracts increased melanin content and tyrosinase activity in a dose-dependent manner. These results suggest that PMR and CWR ethanol extracts could be useful as a skin whitening agent. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한국식품영양과학회 | - |
dc.title | 하수오와 백하수오의 에탄올 추출물에 의한 B16/F10 Melanoma 세포주의 멜라닌 생성 억제효과 | - |
dc.title.alternative | Inhibitory Effects of Ethanol Extracts from Polygoni multiflori radix and Cynanchi wilfordii radix on Melanogenesis in Melanoma Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 박영현 | - |
dc.identifier.bibliographicCitation | 한국식품영양과학회지, v.40, no.8, pp.1086 - 1091 | - |
dc.relation.isPartOf | 한국식품영양과학회지 | - |
dc.citation.title | 한국식품영양과학회지 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1086 | - |
dc.citation.endPage | 1091 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001577533 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Polygoni multiflori radix | - |
dc.subject.keywordAuthor | Cynanchi wilfordii radix | - |
dc.subject.keywordAuthor | melanin | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | antioxidant | - |
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