주관적 기억감퇴를 가진 노인에서 백질 변화와 인지기능 장애의 관련성Relationship between white Matter Changes and Cognitive Dysfunction in the Elderly with Subjective Memory Complaint
- Other Titles
- Relationship between white Matter Changes and Cognitive Dysfunction in the Elderly with Subjective Memory Complaint
- Authors
- 신은영; 정한용; 김양래; 이소영; 김신겸
- Issue Date
- 2011
- Publisher
- 대한생물정신의학회
- Keywords
- White matter changes; Executive function; Cognition; Risk factor.; White matter changes; Executive function; Cognition; Risk factor.
- Citation
- 생물정신의학, v.18, no.3, pp.141 - 147
- Journal Title
- 생물정신의학
- Volume
- 18
- Number
- 3
- Start Page
- 141
- End Page
- 147
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17122
- ISSN
- 1225-8709
- Abstract
- Objectives : The purpose of this study is to evaluate the relationship between the severity of white matter changes (WMC), risk factors and cognitive domains, including executive function profiles.
Method : Forty nine subjects over 55 years with subjective memory complaints were assessed with MRI and neuropsychological tests. The WMC were assessed by MRI T2-FLAIR images and divided into 3 groups of mild vs. moderate vs. severe and 2 groups of mild-moderate vs. severe by using Mäntylä’s criteria and Fazeka’s criteria. The risk factors were examined in hypertension, heart disease history and chemistry Lab. Medical conditions which affect to cognitive dysfunction and definite dementia were also excluded.
Results : Comparing 3 groups, hypertension was identified as a risk factor of the WMC. Comparing 2 groups, total cholesterol and LDL were identified for as the risk factor of WMC. The severity of WMC was significantly associated with cognitive disturbances and their main effect on cognition was working memory and inhibition.
Conclusion : The risk factors of the WMC in the elderly were hypertension, hyperlipidemia. The severity of WMC appears to be associated with executive dysfunction in the elderly.
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Collections - College of Medicine > Department of Psychiatry > 1. Journal Articles
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