유방암 환자에서의 은제자리부합법의 유효성: 체계적 문헌 고찰The Effectiveness of Silver In Situ Hybridization in Patients with Breast Cancer: A Systematic Review
- Other Titles
- The Effectiveness of Silver In Situ Hybridization in Patients with Breast Cancer: A Systematic Review
- Authors
- 장선영; 이선희; 김수진; 이유경; 임영혁; 한원식; 박희숙
- Issue Date
- 2011
- Publisher
- 한국유방암학회
- Keywords
- 유방암; 형광제자리부합법; 체계적 문헌고찰; Breast neoplasms; Fluorescence in situ hybridization; Meta-analysis
- Citation
- Journal of Breast Cancer, v.14, pp 1 - 9
- Pages
- 9
- Journal Title
- Journal of Breast Cancer
- Volume
- 14
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17306
- ISSN
- 1738-6756
2092-9900
- Abstract
- Purpose: The purpose of this study was to evaluate silver in situ hybridization (SISH) as an effective test to identify HER2 gene amplification in patients with breast cancer. Methods: A systematic literature review was used to evaluate the effectiveness of SISH. The literature review covered from October 27, 2009 to December 1, 2009, and eight domestic databases including KoreaMed and foreign databases including Ovid-MEDLINE, EMBASE, and Cochrane Library were used. Keywords, such as ‘silver in situ hybridization’ and ‘SISH’, were used to search 63 documents. Ten studies regarding the evaluation of diagnostics were included in the final evaluation. The Scottish Intercollegiate Guidelines Network (SIGN) tool was used by two evaluators to independently evaluate the quality of the ten studies. Results: A total of ten studies (nine diagnostic evaluation studies and one correlation study) were identified to evaluate SISH. The effectiveness of this test was evaluated based on diagnostic accuracy, concordance rate, and correlation with fluorescence in situ hybridization (FISH) results. The sensitivity of SISH was 0.81-1.00, and the specificity was 0.82-1.00. The positive predictive value was 0.95-1.00, negative predictive value was 0.81-1.00, and the test accuracy was 0.90-1.00. The concordance rate of SISH was 87.0-100% and two studies reported a correlation with FISH results. The body of evidence as a whole suggests a Grade D for SISH. Conclusion: SISH is a safe and useful test in patients with breast cancer and at least grade D evidence based on existing positive studies.
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Collections - College of Medicine > Department of Clinical Pathology > 1. Journal Articles
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