"Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures
- Authors
- Kim, Tae Hyun; Song, Hyun Seok; Jin, Hye Jun; Lee, Sang Hun; Namgung, Seon; Kim, Un-Kyung; Park, Tai Hyun; Hong, Seunghun
- Issue Date
- 2011
- Publisher
- Royal Society of Chemistry
- Citation
- Lab on a Chip, v.11, no.13, pp 2262 - 2267
- Pages
- 6
- Journal Title
- Lab on a Chip
- Volume
- 11
- Number
- 13
- Start Page
- 2262
- End Page
- 2267
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17370
- DOI
- 10.1039/c0lc00648c
- ISSN
- 1473-0197
1473-0189
- Abstract
- We have developed a method to monitor the activities of human taste receptor protein in lipid membrane using carbon nanotube transistors, enabling a "bioelectronic super-taster (BST)", a taste sensor with human-tongue-like selectivity. In this work, human bitter taste receptor protein expressed in E. coli was immobilized on a single-walled carbon nanotube field effect transistor (swCNT-FET) with the lipid membrane. Then, the protein binding activity was monitored using the underlying swCNT-FET, leading to the operation as a BST device. The fabricated BST device could detect bitter tastants at 100 fM concentrations and distinguish between bitter and non-bitter tastants with similar chemical structures just like a human tongue. Furthermore, this strategy was utilized to differentiate the responses of taster or non-taster types of the bitter taste receptor proteins.
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- Appears in
Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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