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Proteomic profiling of the differentially expressed proteins by TiO2 nanoparticles in mouse kidney
- Authors
- Jeon, Yu-Mi; Park, Seul-Ki; Rhee, Sang-Ki; Lee, Mi-Young
- Issue Date
- 31-Dec-2010
- Publisher
- 대한독성 유전단백체 학회
- Keywords
- Proteomics; TiO2 nanoparticles; Mouse; Kidney; Differentially expressed proteins
- Citation
- Molecular & Cellular Toxicology, v.6, no.4, pp 419 - 425
- Pages
- 7
- Journal Title
- Molecular & Cellular Toxicology
- Volume
- 6
- Number
- 4
- Start Page
- 419
- End Page
- 425
- ISSN
- 1738-642X
2092-8467
- Abstract
- We investigated the proteins showing differential expression in response to TiO2 nanoparticles in mouse kidney using a proteomic approach to better understand the molecular mechanism by which TiO2 nanoparticles-induced nephrotoxicity at the protein level. More than 1,100 protein spots in mouse kidney were detected by the two-dimensional gel eletrophoresis and comparative analysis revealed that the expression of 11 proteins were changed by more than 2 fold in response to TiO2 nanoparticles. Of these, 10 were up-regulated and 1 was down-regulated upon treatment with TiO2 nanoparticles.
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Related Researcher
- Lee, Mi young
- College of Medical Sciences (Department of Medical Biotechnology)