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Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report

Authors
Seo, Yu RiKim, Se HyungKim, Hyun JungKim, Chan KyuPark, Seong KyuKoh, Eun SukHong, Dae Sik
Issue Date
20-Jan-2010
Publisher
BioMed Central
Citation
Journal of Hematology and Oncology, v.3
Journal Title
Journal of Hematology and Oncology
Volume
3
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18064
DOI
10.1186/1756-8722-3-4
ISSN
1756-8722
Abstract
No standard has been established for salvage therapy in gemcitabine refractory advanced urothelial cancer. We report the complete response to FOLFOX4 therapy of a metastatic urothelial cancer patient, for whom adjuvant gemcitabine plus cisplatin combination chemotherapy had failed. A 54-year-old male patient with urothelial cancer (transitional cell carcinoma) in the right kidney underwent three rounds of adjuvant gemcitabine-cisplatin chemotherapy after extensive radical nephrectomy. However, he had new liver, lung metastases and synchronous two separate primary colon cancer. The lung metastasis lesion was confirmed as a metastatic urothelial cancer via percutaneous transthoracic needle biopsy (PTNB). Liver and lung metastasis lesions disappeared after the 4th cycle of FOLFOX4 chemotherapy. In addition, colon cancer also disappeared after the 8th cycle of FOLFOX4 chemotherapy. The patient was still showing a complete response after 4 months. Clinical trials using the FOLFOX regimen as salvage therapy for gemcitabine-refractory advanced urothelial cancer are warranted.
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