A Case of Gilbert’s Syndrome with Severe Neonatal HyperbilirubinemiaA Case of Gilbert’s Syndrome with Severe Neonatal Hyperbilirubinemia
- Other Titles
- A Case of Gilbert’s Syndrome with Severe Neonatal Hyperbilirubinemia
- Authors
- Ye-Seul Hong; 진장용; 이우령
- Issue Date
- 2010
- Publisher
- 대한신생아학회
- Keywords
- Gilbert disease; Gilbert’s syndrome; Newborn; Hyperbilirubinemia
- Citation
- Neonatal medicine, v.17, no.2, pp 266 - 269
- Pages
- 4
- Journal Title
- Neonatal medicine
- Volume
- 17
- Number
- 2
- Start Page
- 266
- End Page
- 269
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18234
- ISSN
- 2287-9412
2287-9803
- Abstract
- Gilbert’s syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population has Gilbert’s syndrome.
Commonly, Gilbert’s syndrome causes mild symptoms. However, a case of Gilbert’s syndrome with severe neonatal hyperbilirubinemia is presented here. The patient developed jaundice three days after birth. Five days after birth, the patient’s total serum bilirubin level was 34 mg/dL. The patient received intensive phototherapy and was given oral phenobarbital. Hemolytic hyperbilirubinemia was excluded on the basis of laboratory tests. Heterozygote polymorphisms of the promoter region (-3279T>G)and exon 1 (211G>A) were found in UGT1A1 gene. After discharge, the patient did not require any further treatment. This is the first case of proven Gilbert’s syndrome with severe neonatal hyperbilirubinemia in Korea.
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Collections - College of Medicine > Department of Pediatrics > 1. Journal Articles
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