Long-term survival in a patient with acute promyelocytic leukemia with isolated meningeal relapseLong-term survival in a patient with acute promyelocytic leukemia with isolated meningeal relapse
- Other Titles
- Long-term survival in a patient with acute promyelocytic leukemia with isolated meningeal relapse
- Authors
- 김세형; 윤진아; 김현정; 김찬규; 박성규; 홍대식
- Issue Date
- 2010
- Publisher
- 대한혈액학회
- Keywords
- APL; Extramedullary involvement; CNS
- Citation
- Blood Research, v.45, no.3, pp.208 - 210
- Journal Title
- Blood Research
- Volume
- 45
- Number
- 3
- Start Page
- 208
- End Page
- 210
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18289
- ISSN
- 2287-979X
- Abstract
- The meningeal involvement is rare in acute promyelocytic leukemia. We experienced a 39-year-old woman who achieved complete remission with all-trans retinoic acid, idarubicin and cytarabine therapy. Several months later, she complained of non-specific headache. Her complete blood cell count was normal, but magnetic resonance image of brain revealed focal meningeal enhancement and cerebrospinal fluid showed leukemic promyelocytes and PML/RARA rearrangement. Bone marrow study showed hematologic, cytogenetic and molecular remission. She was treated with intrathecal and systemic chemotherapy and whole brain radiotherapy. The patient has survived for 68 months since the last systemic chemotherapy.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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