Increase Effect of Transforming Growth Factor on Eotaxin Production by Normal Cultured Dermal Fibroblasts Stimulated with Interleukin-4: Inhibitory Effect of Suplatast Tosilate on Eotaxin Production
DC Field | Value | Language |
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dc.contributor.author | Bae, Sang Jae | - |
dc.contributor.author | Lee, Jeong-Beom | - |
dc.contributor.author | Shimizu, Kazuhiro | - |
dc.contributor.author | Kuwazuka, Yutaka | - |
dc.date.accessioned | 2021-08-12T07:34:56Z | - |
dc.date.available | 2021-08-12T07:34:56Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0882-0139 | - |
dc.identifier.issn | 1532-4311 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18580 | - |
dc.description.abstract | Eotaxin plays a central role in the development of allergic disease, including atopic dermatitis, asthma, and nasal allergy. Interleukin (IL)-4 induces eotaxin production in normal human dermal fibroblasts. On the other hands, Transforming growth factor-beta (TGF-beta), a multifunctional regulatory cytokine, affects many biological functions, including fibroblast growth and differentiation and Th2 cytokine regulation. In this study, we investigated the effect of TGF-beta on IL-4-induced eotaxin production by normal human fibroblasts, as well as the effect of suplatast tosilate, an antiallergic drug that selectively inhibits Th2 cytokine production. Dermal fibroblast treatment with IL-4 and TGF-beta for 24 h increased eotaxin production and expression of eotaxin mRNA, as measured by enzyme-linked immunosorbent assay (ELISA) and reverse-transcriptase polymerase chain reaction (RT-PCR), respectively. TGF-beta synergistically up-regulated eotaxin production and eotaxin mRNA expression when stimulated with IL-4. Suplatast tosilate dose-dependently inhibited eotaxin production induced by IL-4 or IL-4 plus TGF-beta. These results suggest that TGF-beta may regulate skin allergic inflammation by up-regulating eotaxin production in dermal fibroblasts. Suplatast tosilate might suppress this inflammation by inhibiting eotaxin production.</. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Marcel Dekker Inc. | - |
dc.title | Increase Effect of Transforming Growth Factor on Eotaxin Production by Normal Cultured Dermal Fibroblasts Stimulated with Interleukin-4: Inhibitory Effect of Suplatast Tosilate on Eotaxin Production | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.3109/08820130903496769 | - |
dc.identifier.scopusid | 2-s2.0-76649107913 | - |
dc.identifier.wosid | 000274857100001 | - |
dc.identifier.bibliographicCitation | Immunological Investigations, v.39, no.2, pp 93 - 102 | - |
dc.citation.title | Immunological Investigations | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 93 | - |
dc.citation.endPage | 102 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TH2 CYTOKINE INHIBITOR | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | EOSINOPHIL CHEMOATTRACTANT | - |
dc.subject.keywordPlus | TISSUE EOSINOPHILIA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordAuthor | Fibroblasts | - |
dc.subject.keywordAuthor | IL-4 | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordAuthor | eotaxin | - |
dc.subject.keywordAuthor | Suplatast tosilate | - |
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