Lack of association between PRNP M129V polymorphism and multiple sclerosis, mild cognitive impairment, alcoholism and schizophrenia in a Korean population
- Authors
- Choi, Ihn-Geun; Woo, Sung-Il; Kim, Ho Jin; Kim, Dai-Jin; Park, Byung Lae; Cheong, Hyun Sub; Pasaje, Charisse Flerida A.; Park, Tae Joon; Bae, Joon Seol; Chai, Young Gyu; Shin, Hyoung Doo
- Issue Date
- 2010
- Publisher
- IOS Press
- Keywords
- Prion; PRNP M129V; multiple sclerosis; mild cognitive impairment; alcoholism; schizophrenia
- Citation
- Disease Markers, v.28, no.5, pp 315 - 321
- Pages
- 7
- Journal Title
- Disease Markers
- Volume
- 28
- Number
- 5
- Start Page
- 315
- End Page
- 321
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18584
- DOI
- 10.1155/2010/196538
- ISSN
- 0278-0240
1875-8630
- Abstract
- The genetic variant at codon 129 (M129V) of the prion protein gene (PRNP) is considered to be a major genetic risk factor for prion diseases. In this study, we examined the possible genetic association of PRNP* 129Val with multiple sclerosis (MS, n = 681), mild cognitive impairment (MCI, n = 801), alcoholism (n = 761) and schizophrenia (n = 715) in a Korean population, and compared the data with previous genetic association studies of the variant. The minor allele frequency of PRNP* 129Val (MAF = 0.025) was significantly lower in Korean population (n = 2,479) compared to Caucasian populations (P < 0.0001), suggestive of a weak influence of the variant in the previous population. Statistical analysis revealed no significant association between PRNP* 129Val and MS (P = 0.76), MCI (P = 0.46), alcoholism (P = 0.84) and schizophrenia (P = 0.69). These findings were discussed in the context of prior inconsistent reports on the role of PRNP* 129Val polymorphism in several diseases. Results from this study may provide further evidence that PRNP M129V is not a genetic susceptibility factor for MS, MCI, alcoholism and schizophrenia in a Korean population.
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Collections - College of Medicine > Department of Psychiatry > 1. Journal Articles
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