Pre-pregnancy metabolic syndrome and insulin administration in gestational diabetes: A nationwide population-based cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Bo-Yeon | - |
dc.contributor.author | Kim, Bongseong | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Chon, Seung Joo | - |
dc.contributor.author | Yoo, Soon Jib | - |
dc.contributor.author | Kim, Kyoung-Kon | - |
dc.date.accessioned | 2021-09-10T05:45:00Z | - |
dc.date.available | 2021-09-10T05:45:00Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1871-403X | - |
dc.identifier.issn | 1878-0318 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18708 | - |
dc.description.abstract | Background: The present study aimed to evaluate whether mothers with obesity/central obesity and metabolic syndrome before gestation are at higher risk of insulin administration in gestational diabetes mellitus (GDM) to diminish the burden of insulin use during pregnancy. Methods: This was a population-based retrospective cohort study conducted using data from the National Health Information Database of Korea. We identified all deliveries from January 1, 2011 to December 31, 2015 (N = 1,214,655). Among the deliveries, we identified mothers with pre-pregnancy health checkup records and without previous diabetes history (N = 325,208). Hazards of insulin use in GDM were calculated based on pre-pregnancy obesity/central obesity and metabolic syndrome. Results: Hazards of insulin use in GDM increased proportionately with an increase in the pre-pregnancy body mass index (BMI) and waist circumference (WC). After the adjustment for clinical factors, high BMI group (>= 30 kg/m(2)) and high WC group (>= 100 cm) were significantly associated with higher hazard ratios (HRs) (HR 4.161, 95% Confidence interval [CI] 3.381-5.121, P < 0.001 and HR 2.563, 95% CI 1.769-3.712, P < 0.001, respectively). The presence of pre-pregnancy metabolic syndrome significantly increased the hazard of insulin use in GDM (0.54% vs. 5.04%). In the presence of obesity (BMI >= 25 kg/m(2)) or central obesity (WC >= 85 cm), HRs of insulin use in GDM were 2.637 (95% CI 2.275-3.056) and 1.603 (95% CI 1.023-2.511), respectively, after adjustment for clinical factors. Conclusions: The presence of pre-pregnancy obesity/central obesity and metabolic syndrome in Korean mothers is associated with increased risk of insulin use in GDM. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Pre-pregnancy metabolic syndrome and insulin administration in gestational diabetes: A nationwide population-based cohort study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.orcp.2021.06.004 | - |
dc.identifier.scopusid | 2-s2.0-85109082051 | - |
dc.identifier.wosid | 000675529000009 | - |
dc.identifier.bibliographicCitation | Obesity Research and Clinical Practice, v.15, no.4, pp 362 - 367 | - |
dc.citation.title | Obesity Research and Clinical Practice | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 362 | - |
dc.citation.endPage | 367 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | MATERNAL OBESITY | - |
dc.subject.keywordPlus | MACROSOMIA | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordAuthor | Gestational diabetes | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
dc.subject.keywordAuthor | Obesity | - |
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